The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.

Animals Glutamates Hepatic Stellate Cells Hepatocytes Liver Diseases, Alcoholic Macrophages Mice

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
05 11 2019
Historique:
entrez: 7 11 2019
pubmed: 7 11 2019
medline: 21 5 2020
Statut: ppublish

Résumé

Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key components of the xCT-glutamate→mGluR5-2-AG→CB

Identifiants

DOI: 10.1016/j.cmet.2019.10.010 PMID: 31693880
pubmed: 31693880
pii: S1550-4131(19)30566-2
doi: 10.1016/j.cmet.2019.10.010
pii:
doi:

Substances chimiques

Glutamates 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

850-852

Subventions

Organisme : NIAAA NIH HHS
ID : P50 AA011999
Pays : United States

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Tatiana Kisseleva (T)

Department of Surgery, University of California, San Diego, San Diego, CA 92093, USA. Electronic address: tkisseleva@ucsd.edu.

David A Brenner (DA)

Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA. Electronic address: dbrenner@ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Crosstalk between Hepatocytes, Hepatic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés dicarboxyliques › Glutamates › The Crosstalk between Hepatocytes, Hepatic...
questionsmedicales.fr › Cellules › Cellules étoilées du foie › The Crosstalk between Hepatocytes, Hepatic...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › The Crosstalk between Hepatocytes, Hepatic...
questionsmedicales.fr › Troubles dus à des produits chimiques › Troubles dus à l'abus d'alcool › Maladies alcooliques du foie › The Crosstalk between Hepatocytes, Hepatic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › The Crosstalk between Hepatocytes, Hepatic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Crosstalk between Hepatocytes, Hepatic...