Carcinogenesis and Metastasis in Liver: Cell Physiological Basis.
VEGF
circadian homeostasis
cortisol
hepatic stellate cells
hepatocellular carcinoma
immunity
myofibroblasts
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Nov 2019
05 Nov 2019
Historique:
received:
20
09
2019
revised:
29
10
2019
accepted:
01
11
2019
entrez:
8
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) incidence is rising. This paper summarises the current state of knowledge and recent discoveries in the cellular and physiological mechanisms leading to the development of liver cancer, especially HCC, and liver metastases. After reviewing normal hepatic cytoarchitecture and immunological characteristics, the paper addresses the pathophysiological factors that cause liver damage and predispose to neoplasia. Particular attention is given to chronic liver diseases, metabolic syndrome and the impact of altered gut microbiota, disrupted circadian rhythm and psychological stress. Improved knowledge of the multifactorial aetiology of HCC has important implications for the prevention and treatment of this cancer and of liver metastases in general.
Identifiants
pubmed: 31694274
pii: cancers11111731
doi: 10.3390/cancers11111731
pmc: PMC6895858
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : CRO 5X1000_2010_MdS, Italy
ID : CRO 5X1000_2010_MdS
Références
Am J Pathol. 2016 Mar;186(3):539-51
pubmed: 26773351
Front Pharmacol. 2014 Jul 22;5:167
pubmed: 25100997
Annu Rev Pathol. 2018 Jan 24;13:351-378
pubmed: 29125798
Science. 2018 Sep 28;361(6409):
pubmed: 30262472
World J Gastrointest Pathophysiol. 2014 May 15;5(2):107-13
pubmed: 24891982
Trends Immunol. 2014 Nov;35(11):507-17
pubmed: 25172617
World J Gastroenterol. 2019 Jul 7;25(25):3123-3135
pubmed: 31333306
Antioxid Redox Signal. 2006 May-Jun;8(5-6):1047-58
pubmed: 16771694
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Curr Opin Immunol. 2015 Feb;32:1-6
pubmed: 25463592
Gastroenterology. 2016 Dec;151(6):1176-1191
pubmed: 27569723
Ann Hepatol. 2016 Mar-Apr;15(2):160-73
pubmed: 26845593
Clin Chem. 2013 Sep;59(9):1384-92
pubmed: 23695297
BMC Gastroenterol. 2014 Jul 03;14:117
pubmed: 24990270
J Autoimmun. 2016 Jan;66:60-75
pubmed: 26358406
Lancet. 2019 Apr 6;393(10179):1453-1464
pubmed: 30765123
Cell Mol Immunol. 2016 May;13(3):267-76
pubmed: 27063467
Cancer Metastasis Rev. 2019 Jun;38(1-2):205-222
pubmed: 30911978
Dig Dis Sci. 2017 Dec;62(12):3495-3500
pubmed: 29043595
Int J Cell Biol. 2012;2012:762825
pubmed: 22666258
Int J Mol Sci. 2016 May 20;17(5):
pubmed: 27213358
Obes Res Clin Pract. 2013 Sep-Oct;7(5):e330-41
pubmed: 24455761
Oncotarget. 2018 Jan 6;9(11):9925-9939
pubmed: 29515780
Am J Pathol. 2009 Jul;175(1):355-64
pubmed: 19541928
Ther Adv Med Oncol. 2019 May 10;11:1758835919848184
pubmed: 31205505
Cancer Res. 2013 Mar 15;73(6):1721-32
pubmed: 23345161
Science. 2017 Oct 6;358(6359):111-116
pubmed: 28983053
World J Gastroenterol. 2016 Dec 28;22(48):10512-10522
pubmed: 28082803
Appl Microbiol Biotechnol. 2017 Jan;101(1):47-64
pubmed: 27888332
Semin Immunopathol. 2009 Sep;31(3):333-43
pubmed: 19639317
Oxid Med Cell Longev. 2017;2017:3831972
pubmed: 28357027
Med Hypotheses. 2005;64(4):751-4
pubmed: 15694692
J Enzymol Metab. 2015;1(1):
pubmed: 26937490
Sci Rep. 2018 Sep 21;8(1):14184
pubmed: 30242285
Curr Drug Targets. 2015;16(12):1324-31
pubmed: 25882223
Hepatology. 2012 Nov;56(5):1971-82
pubmed: 22532075
J Immunol. 2015 Apr 1;194(7):3213-22
pubmed: 25712214
Cells. 2017 Dec 07;6(4):
pubmed: 29215603
J Transl Med. 2018 Mar 20;16(1):75
pubmed: 29558948
Gastroenterology. 2014 Sep;147(3):577-594.e1
pubmed: 25066692
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
Cancer Res. 2011 Nov 15;71(22):6921-5
pubmed: 22084445
Antioxid Redox Signal. 2007 Aug;9(8):1115-24
pubmed: 17567242
Nat Rev Gastroenterol Hepatol. 2019 Feb;16(2):80-82
pubmed: 30559444
Hepatology. 2011 Oct;54(4):1379-87
pubmed: 21721032
Int J Mol Sci. 2019 Apr 07;20(7):
pubmed: 30959975
Eur J Nutr. 2018 May;57(Suppl 1):1-14
pubmed: 29748817
World J Gastroenterol. 2019 Aug 7;25(29):3929-3940
pubmed: 31413528
Int J Mol Sci. 2019 Jan 30;20(3):
pubmed: 30704150
Hepatogastroenterology. 2013 Jul-Aug;60(125):1164-8
pubmed: 23803379
Immunol Rev. 2000 Apr;174:5-20
pubmed: 10807503
Nat Rev Gastroenterol Hepatol. 2017 Sep;14(9):527-539
pubmed: 28676707
Mol Aspects Med. 2019 Feb;65:37-55
pubmed: 30213667
Front Immunol. 2019 Apr 30;10:946
pubmed: 31114585
BMJ. 2014 Jul 29;349:g4596
pubmed: 25239614
Nat Med. 2016 Oct 06;22(10):1079-1089
pubmed: 27711063
Cancer Discov. 2017 May;7(5):522-538
pubmed: 28202625
Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G849-62
pubmed: 24650547
Clin Gastroenterol Hepatol. 2019 Jan;17(2):353-361
pubmed: 30055267
Cancer Cell. 2016 Dec 12;30(6):909-924
pubmed: 27889186
Sci Rep. 2018 Apr 18;8(1):6220
pubmed: 29670256
J Hepatol. 1998 Jan;28(1):84-90
pubmed: 9537869
Dev Dyn. 2015 Mar;244(3):497-506
pubmed: 25370311
Gene Expr. 2019 Apr 18;19(2):69-87
pubmed: 30646969
Int J Oncol. 2013 Nov;43(5):1333-42
pubmed: 23969900
J Viral Hepat. 2018 May;25(5):442-456
pubmed: 29397014
Expert Rev Gastroenterol Hepatol. 2014 May;8(4):369-82
pubmed: 24597926
J Hepatol. 2017 Jun;66(6):1300-1312
pubmed: 28267621
Br J Cancer. 2016 Jun 28;115(1):34-9
pubmed: 27280634
Curr Protein Pept Sci. 2018;19(12):1172-1179
pubmed: 29150921
Jpn J Cancer Res. 2002 Jul;93(7):729-35
pubmed: 12149137
Cell Biosci. 2019 Sep 26;9:79
pubmed: 31572568
Mucosal Immunol. 2019 Jul;12(4):851-861
pubmed: 30952999
Curr Opin Lipidol. 2019 Jun;30(3):235-243
pubmed: 30893110
Dig Liver Dis. 2010 May;42(5):341-7
pubmed: 19828388
Annu Rev Immunol. 2018 Apr 26;36:247-277
pubmed: 29328785
Arch Intern Med. 1999 Dec 13-27;159(22):2647-58
pubmed: 10597755
Int J Cancer. 2007 Dec 1;121(11):2373-80
pubmed: 17893866
Nature. 2006 Apr 27;440(7088):1222-6
pubmed: 16642001
Mediators Inflamm. 2018 Dec 30;2018:1218297
pubmed: 30692870
Ann Surg. 2002 Mar;235(3):373-82
pubmed: 11882759
Sci Transl Med. 2018 Apr 18;10(437):
pubmed: 29669855
Lancet. 2018 Mar 24;391(10126):1174-1185
pubmed: 29519502
Med Sci Monit. 2019 Sep 03;25:6615-6623
pubmed: 31479436
Hepatology. 2006 Feb;43(2 Suppl 1):S54-62
pubmed: 16447271
Eur J Cancer. 2017 Dec;87:101-112
pubmed: 29145036
Hepatology. 2015 Oct;62(4):1272-84
pubmed: 26173184
N Engl J Med. 1997 Jun 26;336(26):1855-9
pubmed: 9197213
Breast Cancer Res Treat. 2017 Nov;166(1):289-297
pubmed: 28741275
J Intern Med. 2019 Jul;286(1):32-40
pubmed: 30873652
Lancet. 2003 May 3;361(9368):1502-10
pubmed: 12737859
World J Clin Oncol. 2019 Aug 24;10(8):279-282
pubmed: 31528543
Eur J Immunol. 2004 Jan;34(1):126-36
pubmed: 14971038
J Carcinog. 2017 May 29;16:1
pubmed: 28694740
Dev Cell. 2009 Feb;16(2):196-208
pubmed: 19217422
Aliment Pharmacol Ther. 2015 May;41(10):917-27
pubmed: 25809237
World J Gastroenterol. 2019 May 21;25(19):2279-2293
pubmed: 31148900
Graefes Arch Clin Exp Ophthalmol. 2017 Sep;255(9):1757-1762
pubmed: 28631245
Immunol Rev. 2016 Sep;273(1):11-28
pubmed: 27558325
Dis Model Mech. 2018 Oct 24;11(10):
pubmed: 30355585
Hepatology. 2015 Mar;61(3):1066-79
pubmed: 25066777
PLoS One. 2018 Mar 7;13(3):e0193824
pubmed: 29513725
Liver Res. 2018 Mar;2(1):43-51
pubmed: 30416839
World J Clin Oncol. 2018 Sep 14;9(5):74-82
pubmed: 30254962
PLoS One. 2015 Feb 20;10(2):e0117420
pubmed: 25700262
Int J Mol Sci. 2019 Jan 17;20(2):
pubmed: 30658519
Cancer Cell. 2016 Dec 12;30(6):827-828
pubmed: 27960079
Semin Liver Dis. 2018 Nov;38(4):340-350
pubmed: 30357771
Science. 1956 Feb 24;123(3191):309-14
pubmed: 13298683