[Safety signal detection by the French Addictovigilance Network: Innovative methods of investigation, examples and usefulness for public health].
Détection des signaux du réseau français d’addictovigilance : méthodes innovantes d’investigation, illustrations et utilité pour la santé publique.
Adverse Drug Reaction Reporting Systems
/ organization & administration
Community Networks
/ organization & administration
Data Collection
/ methods
Databases, Factual
France
/ epidemiology
Humans
Mandatory Reporting
Organizational Innovation
Pharmacies
/ organization & administration
Pharmacovigilance
Prescription Drugs
/ supply & distribution
Product Surveillance, Postmarketing
/ methods
Psychotropic Drugs
/ supply & distribution
Public Health
/ methods
Substance-Related Disorders
/ diagnosis
Abus de produits
Addictovigilance
Detection
Drug abuse
Détection
Methods
Monitoring
Méthodes
Signal
Surveillance
Journal
Therapie
ISSN: 1958-5578
Titre abrégé: Therapie
Pays: France
ID NLM: 0420544
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
14
08
2019
revised:
26
08
2019
accepted:
26
08
2019
pubmed:
7
11
2019
medline:
30
4
2020
entrez:
8
11
2019
Statut:
ppublish
Résumé
The French Addictovigilance Network aims to monitor all psychoactive substances with abuse potential including prescription drugs and other legal and illegal substances such as new psychoactive substances (NPS) and its consequences in humans. Created in 1990 through a network of regional addictovigilance centres covering the entire country, these pharmacologists with expertise in addictovigilance have developed interface with different partners (physicians, toxicologists, network of community pharmacies, addictology care centers…) and implemented several original tools of pharmacosurveillance (such as DRAMES [death related to the abuse of medicines] in strong collaboration with toxicologists or such OPPIDUM [observation of illegal products and misuse of psychotropic medications]), complementary to the spontaneous reporting. A such multidimensional approach including proactive surveillance by these tools and also among several heterogenous data sources (such as data from hospitals or claims database) is able to detect early addictovigilance signals and warnings as illustrated with three following examples: cannabis use and acute serious cardiovascular disorders, new synthetic opioids (ocfentanil, carfentanil) and severe opiate overdose or deaths, the diverted use of psychoactive drugs (codeine analgesics or sedative H1 antihistamines called purple drank) by adolescents and young adults. The choice of a broad strategy and the multifaceted system implemented by the French Addictovigilance Network using elements of pharmacology (fundamental, clinical, pharmacoepidemiology) expertise is an innovative method to detect early addictovigilance signals, and to describe its characteristics in order to increase awareness of psychoactive substances by patients, users and health professionals.
Identifiants
pubmed: 31694770
pii: S0040-5957(19)30149-0
doi: 10.1016/j.therap.2019.09.005
pii:
doi:
Substances chimiques
Prescription Drugs
0
Psychotropic Drugs
0
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
579-590Informations de copyright
Copyright © 2019 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.