Six critical questions for DNA repair enzymes in skincare products: a review in dialog.
DNA repair
T4 endonuclease V
UV endonuclease
actinic keratosis
photolyase
skin cancer
Journal
Clinical, cosmetic and investigational dermatology
ISSN: 1178-7015
Titre abrégé: Clin Cosmet Investig Dermatol
Pays: New Zealand
ID NLM: 101543449
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
06
2019
accepted:
13
08
2019
entrez:
8
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
Concerns over existing sunscreen filters have reinforced the need to examine supplemental sun protection or repair of sun damage. Technology to enhance DNA repair has been available in skincare and sunscreen products for several decades, but skepticism and lack of familiarity with the supporting data remain prevalent. Here, we address six of the main questions raised by medical professionals regarding the efficacy of DNA repair enzymes in sun protection. These include the mode of delivery and mechanism of action, the effect on cellular responses and the amelioration of pre-cancers, cancers and photoaging. The conclusions are that topical DNA repair enzymes do enhance removal of DNA damage and reduce the appearance of new actinic keratoses as well as increase regression of existing lesions. Support for prevention of photoaging and skin cancer is significant but could be strengthened or disproven with additional research.
Identifiants
pubmed: 31695467
doi: 10.2147/CCID.S220741
pii: 220741
pmc: PMC6718248
doi:
Types de publication
Journal Article
Langues
eng
Pagination
617-624Informations de copyright
© 2019 Yarosh et al.
Déclaration de conflit d'intérêts
Daniel Yarosh consults for Pharma Cosmetics Inc. Ronald Moy is the scientific director and founder of DNA EGF Renewal and Cellular MD. The authors report no other conflicts of interest in this work.
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