MicroRNA And Circular RNA Expression In Affected Skin Of Patients With Postherpetic Neuralgia.
circular RNA
microRNA
neuropathic pain
postherpetic neuralgia
Journal
Journal of pain research
ISSN: 1178-7090
Titre abrégé: J Pain Res
Pays: New Zealand
ID NLM: 101540514
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
07
2019
accepted:
30
09
2019
entrez:
8
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
Mechanisms of postherpetic neuralgia (PHN) are still not clear. Transcripts such as microRNA (miRNA) and circular RNA (circRNA) in the affected skin may take part in the initiation and development of this neuropathic pain; however, their expression profiles in skins of PHN patients have not been reported. The PHN affected skin and the mirror skin were collected and subjected to miRNA and circRNA microarray, and expression profiles were comparatively analyzed. There were 317 differently expressed miRNAs in PHN affected skin compared with mirror skin (fold change ≥2.0), and 13 of them showed fold change >10 in the PHN skin. Only one circRNA, hsa_circRNA_405463 showed fold change >2 in PHN skin, however, 31 circRNAs with fold change ≥1.5. To evaluate functions of differential miRNAs, their target mRNAs were predicted and bioinformatics analyses including gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway were conducted. Target mRNAs significantly (P<0.05) enriched in 85 pathways, such as FoxO, AMPK, MAPK and pathway. These data reported for the first time that miRNA and circRNA differentially expressed in the PHN skin and these transcripts with abnormal expression could be potential targets to treat PHN.
Identifiants
pubmed: 31695480
doi: 10.2147/JPR.S221615
pii: 221615
pmc: PMC6802488
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2905-2913Informations de copyright
© 2019 Cao et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Lancet Neurol. 2010 Aug;9(8):807-19
pubmed: 20650402
Diabetes. 2018 Jan;67(1):98-109
pubmed: 29025860
Nat Rev Neurosci. 2018 Mar;19(3):138-152
pubmed: 29416128
J Transl Med. 2016 Jul 28;14(1):225
pubmed: 27465405
Ann Neurol. 1995 Feb;37(2):246-53
pubmed: 7847866
Biomed Pharmacother. 2018 Dec;108:996-1004
pubmed: 30372911
Pain Rep. 2018 Nov 07;3(6):e702
pubmed: 30706041
Glia. 2018 Nov;66(11):2299-2315
pubmed: 30417431
Pain. 2016 Nov;157(11):2493-2503
pubmed: 27429177
Front Mol Neurosci. 2017 Apr 03;10:91
pubmed: 28420964
Nat Commun. 2016 Apr 06;7:11215
pubmed: 27050392
Medicine (Baltimore). 2017 Feb;96(8):e5997
pubmed: 28225487
Curr Drug Metab. 2016;17(4):336-44
pubmed: 26467071
Immun Ageing. 2015 Oct 08;12:17
pubmed: 26451160
J Pain Res. 2017 Nov 14;10:2665-2674
pubmed: 29180893
Am J Transl Res. 2018 Jan 15;10(1):184-199
pubmed: 29423004
Biochem Biophys Res Commun. 2018 Mar 4;497(2):790-796
pubmed: 29470979
BMJ Open. 2016 Feb 18;6(2):e009689
pubmed: 26892790
Diabetes. 2018 Aug;67(8):1627-1638
pubmed: 29748291
Cell Res. 2017 Jul;27(7):882-897
pubmed: 28429770
Glia. 2011 Apr;59(4):554-68
pubmed: 21319222
Science. 2013 Apr 26;340(6131):440-1
pubmed: 23620042
Exp Neurol. 2016 Sep;283(Pt A):276-86
pubmed: 27349406
Brain Behav. 2016 Nov 04;7(1):e00587
pubmed: 28127509
J Neuroinflammation. 2019 Feb 12;16(1):34
pubmed: 30755236
Pain Physician. 2017 Feb;20(2):E303-E314
pubmed: 28158166
Wiley Interdiscip Rev RNA. 2017 Jul;8(4):
pubmed: 28130830
Neurobiol Dis. 2014 Nov;71:159-68
pubmed: 25119878
Oxid Med Cell Longev. 2015;2015:756576
pubmed: 26171116
Nat Rev Genet. 2016 May;17(5):272-83
pubmed: 27040487
Nature. 2013 Mar 21;495(7441):333-8
pubmed: 23446348
J Pain Res. 2017 Jul 17;10:1687-1696
pubmed: 28761373
Pain Physician. 2017 Jul;20(5):E687-E699
pubmed: 28727713
J Pain. 2008 Jan;9(1 Suppl 1):S10-8
pubmed: 18166461
Curr Med Chem. 2014;21(38):4405-18
pubmed: 25245374
Neurol Sci. 2014 Apr;35(4):531-6
pubmed: 24057116
J Neurol Sci. 2017 Sep 15;380:242-249
pubmed: 28870579
Biochem Biophys Res Commun. 2018 Nov 2;505(3):644-650
pubmed: 30286957
Nature. 2013 Mar 21;495(7441):384-8
pubmed: 23446346
Expert Opin Ther Targets. 2018 Feb;22(2):131-142
pubmed: 29285962
Genome Biol. 2003;5(1):R1
pubmed: 14709173
J Palliat Med. 2011 Jun;14(6):765-73
pubmed: 21651364