Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.
Cellular senescence
Endurance
Ergogenic aid
Inflammation
Macrophage
Journal
Journal of ginseng research
ISSN: 1226-8453
Titre abrégé: J Ginseng Res
Pays: Korea (South)
ID NLM: 100890690
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
13
04
2018
revised:
08
06
2018
accepted:
14
06
2018
entrez:
8
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
ppublish
Résumé
Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-β-gal) in cultured cells. It remains unknown whether Rg1 can influence SA-β-gal in exercising human skeletal muscle. To examine SA-β-gal change, 12 young men (age 21 ± 0.2 years) were enrolled in a randomized double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg) supplementations 1 h prior to a high-intensity cycling (70% VO No changes of SA-β-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12 participants showed complete elimination of SA-β-gal in exercised muscle after cycling in the Rg1 trial ( Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal muscle and improves high-intensity endurance performance.
Sections du résumé
BACKGROUND
BACKGROUND
Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-β-gal) in cultured cells. It remains unknown whether Rg1 can influence SA-β-gal in exercising human skeletal muscle.
METHODS
METHODS
To examine SA-β-gal change, 12 young men (age 21 ± 0.2 years) were enrolled in a randomized double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg) supplementations 1 h prior to a high-intensity cycling (70% VO
RESULTS
RESULTS
No changes of SA-β-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12 participants showed complete elimination of SA-β-gal in exercised muscle after cycling in the Rg1 trial (
CONCLUSION
CONCLUSIONS
Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal muscle and improves high-intensity endurance performance.
Identifiants
pubmed: 31695564
doi: 10.1016/j.jgr.2018.06.002
pii: S1226-8453(18)30113-1
pmc: PMC6823780
doi:
Types de publication
Journal Article
Langues
eng
Pagination
580-588Informations de copyright
© 2018 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
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