Cancer Sample Biobanking at the Next Level: Combining Tissue With Living Cell Repositories to Promote Precision Medicine.

living cell biobanking organoids patient-derived tumor models personalized medicine tissue biobanking

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2019
Historique:
received: 16 07 2019
accepted: 07 10 2019
entrez: 8 11 2019
pubmed: 7 11 2019
medline: 7 11 2019
Statut: epublish

Résumé

Biorespositories of formalin-fixed and paraffin-embedded (FFPE) or fresh frozen human tissues from malignant diseases generated as integral part of the diagnostic workup in many pathology departments have been pivotal resources for translational cancer studies. However, such tissue biobanks have traditionally contained only non-viable specimens and thus cannot enable functional assays for the discovery and validation of therapeutic targets or the assessment of drug responses and resistance to treatment. To overcome these limitations, we have developed a next-generation comprehensive biobanking platform that includes the generation of patient-derived

Identifiants

pubmed: 31696117
doi: 10.3389/fcell.2019.00246
pmc: PMC6817465
doi:

Types de publication

Journal Article

Langues

eng

Pagination

246

Informations de copyright

Copyright © 2019 Bolck, Pauli, Göbel, Mühlbauer, Dettwiler, Moch and Schraml.

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Auteurs

Hella A Bolck (HA)

Department of Pathology and Molecular Pathology, University Hospital of Zürich, Zurich, Switzerland.

Chantal Pauli (C)

Department of Pathology and Molecular Pathology, University Hospital of Zürich, Zurich, Switzerland.

Elisabeth Göbel (E)

Department of Pathology and Molecular Pathology, University Hospital of Zürich, Zurich, Switzerland.

Katharina Mühlbauer (K)

Department of Pathology and Molecular Pathology, University Hospital of Zürich, Zurich, Switzerland.

Susanne Dettwiler (S)

Department of Pathology and Molecular Pathology, University Hospital of Zürich, Zurich, Switzerland.

Holger Moch (H)

Department of Pathology and Molecular Pathology, University Hospital of Zürich, Zurich, Switzerland.

Peter Schraml (P)

Department of Pathology and Molecular Pathology, University Hospital of Zürich, Zurich, Switzerland.

Classifications MeSH