White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease.
Kawasaki disease
intravenous immunoglobulin
neutrophil counts
nonresponder
white blood cell counts
Journal
Global pediatric health
ISSN: 2333-794X
Titre abrégé: Glob Pediatr Health
Pays: United States
ID NLM: 101670224
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
06
2019
revised:
20
08
2019
accepted:
13
09
2019
entrez:
8
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
We explored parameters to predicting the efficacy of intravenous immunoglobulin (IVIG) therapy for patients with Kawasaki disease (KD). We retrospectively analyzed the laboratory data of 77 children with KD treated with IVIG. Data obtained before and within 24 hours after IVIG therapy were compared between responders and nonresponders. The white blood cell (WBC) and neutrophil counts were significantly lower in responders than nonresponders within 24 hours after IVIG. The areas under the receiver operating characteristics curves of the WBC and neutrophil counts were 0.846 and 0.754, respectively. The WBC and neutrophil counts differed significantly between responders and nonresponders (the latter developed recurrent pyrexia after transient fever resolution). In conclusion, WBC and neutrophil counts within 24 hours after IVIG usefully predict the efficacy of IVIG therapy for those with KD, and identify nonresponders to such therapy.
Identifiants
pubmed: 31696148
doi: 10.1177/2333794X19884826
pii: 10.1177_2333794X19884826
pmc: PMC6820171
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2333794X19884826Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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