Berkson's paradox and weighted distributions: An application to Alzheimer's disease.

ABC rejection algorithm Alzheimer's disease Berkson's fallacy biased sampling likelihood-free inference

Journal

Biometrical journal. Biometrische Zeitschrift
ISSN: 1521-4036
Titre abrégé: Biom J
Pays: Germany
ID NLM: 7708048

Informations de publication

Date de publication:
01 2020
Historique:
received: 15 01 2019
revised: 11 09 2019
accepted: 18 09 2019
pubmed: 8 11 2019
medline: 29 12 2020
entrez: 8 11 2019
Statut: ppublish

Résumé

One reason for observing in practice a false positive or negative correlation between two random variables, which are either not correlated or correlated with a different direction, is the overrepresentation in the sample of individuals satisfying specific properties. In 1946, Berkson first illustrated the presence of a false correlation due to this last reason, which is known as Berkson's paradox and is one of the most famous paradox in probability and statistics. In this paper, the concept of weighted distributions is utilized to describe Berskon's paradox. Moreover, a proper procedure is suggested to make inference for the population given a biased sample which possesses all the characteristics of Berkson's paradox. A real data application for patients with dementia due to Alzheimer's disease demonstrates that the proposed method reveals characteristics of the population that are masked by the sampling procedure.

Identifiants

pubmed: 31696967
doi: 10.1002/bimj.201900046
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

238-249

Subventions

Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : CIHR
Pays : Canada

Informations de copyright

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Polychronis Economou (P)

Department of Civil Engineering, University of Patras, Rion-Patras, Greece.

Apostolos Batsidis (A)

Department of Mathematics, University of Ioannina, Ioannina, Greece.

George Tzavelas (G)

Department of Statistics and Insurance Science, University of Piraeus, Piraeus, Greece.

Panagiotis Alexopoulos (P)

Department of Psychiatry, Faculty of Medicine, University of Patras, University Hospital of Rion, Rion Patras, Greece.
Department of Psychiatry and Psychotherapy, Faculty of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.

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