Progesterone increases the incidence of bovine herpesvirus 1 reactivation from latency and stimulates productive infection.
Animals
Antibodies, Viral
Cattle
Cattle Diseases
/ immunology
Female
Herpesviridae Infections
/ veterinary
Herpesvirus 1, Bovine
/ physiology
Male
Progesterone
/ metabolism
Rabbits
Sex Factors
Virus Activation
/ drug effects
Virus Latency
/ drug effects
Virus Replication
/ drug effects
Virus Shedding
Abortion
Bovine herpesvirus 1 (BoHV-1)
Progesterone
Reactivation from latency
Journal
Virus research
ISSN: 1872-7492
Titre abrégé: Virus Res
Pays: Netherlands
ID NLM: 8410979
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
05
09
2019
revised:
30
10
2019
accepted:
01
11
2019
pubmed:
8
11
2019
medline:
18
11
2020
entrez:
8
11
2019
Statut:
ppublish
Résumé
Bovine herpesvirus 1 (BoHV-1), including modified live vaccines, can cause abortions in pregnant cows. Progesterone maintains pregnancy and promotes spermiogenesis and testosterone biosynthesis in males: furthermore, progesterone is a neuro-steroid. Recent published studies demonstrated progesterone stimulated the BoHV-1 immediate early transcription unit 1 (IEtu1) promoter, and two glucocorticoid receptor response elements within the promoter were required for progesterone mediated transactivation. In this study, we tested whether progesterone induces reactivation from latency in rabbits. As expected, the synthetic corticosteroid dexamethasone consistently induced reactivation from latency in males and females. While progesterone induced reactivation from latency in approximately one-half of male rabbits, virus shedding was sporadic compared to dexamethasone and less efficient in female rabbits. Progesterone significantly increased productive infection in rabbit skin cells, which correlated with stimulating reactivation. These studies suggest progesterone promotes BoHV-1 spread in cattle, in part, by increasing the frequency of reactivation from latency.
Identifiants
pubmed: 31697987
pii: S0168-1702(19)30639-2
doi: 10.1016/j.virusres.2019.197803
pmc: PMC7068234
mid: NIHMS1543279
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Progesterone
4G7DS2Q64Y
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
197803Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103648
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS102290
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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