Long-term Respiratory Effects of Mustard Vesicants.
Lung injury
Mustard vesicant
Pulmonary fibrosis
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
01 Feb 2020
01 Feb 2020
Historique:
received:
12
09
2019
revised:
24
10
2019
accepted:
29
10
2019
pubmed:
8
11
2019
medline:
31
12
2019
entrez:
8
11
2019
Statut:
ppublish
Résumé
Sulfur mustard and related vesicants are cytotoxic alkylating agents that cause severe damage to the respiratory tract. Injury is progressive leading, over time, to asthma, bronchitis, bronchiectasis, airway stenosis, and pulmonary fibrosis. As there are no specific therapeutics available for victims of mustard gas poisoning, current clinical treatments mostly provide only symptomatic relief. In this article, the long-term effects of mustards on the respiratory tract are described in humans and experimental animal models in an effort to define cellular and molecular mechanisms contributing to lung injury and disease pathogenesis. A better understanding of mechanisms underlying pulmonary toxicity induced by mustards may help in identifying potential targets for the development of effective clinical therapeutics aimed at mitigating their adverse effects.
Identifiants
pubmed: 31698045
pii: S0378-4274(19)30351-0
doi: 10.1016/j.toxlet.2019.10.026
pmc: PMC10266484
mid: NIHMS1902484
pii:
doi:
Substances chimiques
Alkylating Agents
0
Chemical Warfare Agents
0
Mustard Compounds
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-174Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES004738
Pays : United States
Organisme : NIAMS NIH HHS
ID : U54 AR055073
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
Références
Int Immunopharmacol. 2009 Dec;9(13-14):1482-8
pubmed: 19748599
Toxicol Lett. 2019 Mar 15;303:9-15
pubmed: 30572106
Int Immunopharmacol. 2009 Dec;9(13-14):1471-6
pubmed: 19735741
Drug Chem Toxicol. 2016;39(2):182-9
pubmed: 26247826
Toxicol Appl Pharmacol. 2010 Oct 15;248(2):89-99
pubmed: 20659490
Toxicol Mech Methods. 2013 Nov;23(9):702-10
pubmed: 24024669
Chest. 1997 Sep;112(3):734-8
pubmed: 9315808
Toxicol Lett. 2016 Feb 26;244:2-7
pubmed: 26478570
Toxicol Sci. 2015 Jan;143(1):178-84
pubmed: 25331496
Toxicol Appl Pharmacol. 2012 Dec 15;265(3):279-91
pubmed: 22981630
Toxicology. 2009 Sep 1;263(1):9-11
pubmed: 19486919
Curr Ther Res Clin Exp. 2004 Nov;65(6):495-504
pubmed: 24672101
Hum Exp Toxicol. 2018 Feb;37(2):175-184
pubmed: 29320941
Exp Lung Res. 2010 Jun;36(5):284-91
pubmed: 20497023
J Clin Immunol. 2007 Nov;27(6):605-12
pubmed: 17620002
J Appl Toxicol. 2014 Mar;34(3):272-80
pubmed: 23625772
Laeknabladid. 2009 May;95(5):359-65
pubmed: 19430031
Int Immunopharmacol. 2009 Dec;9(13-14):1499-503
pubmed: 19733693
Am J Respir Cell Mol Biol. 2018 Jun;58(6):696-705
pubmed: 29314868
Lancet. 1968 Jun 1;1(7553):1161-3
pubmed: 4172287
Inhal Toxicol. 2016 Jul;28(8):343-8
pubmed: 27109836
Toxicol Sci. 2018 Nov 1;166(1):108-122
pubmed: 30060251
Iran J Allergy Asthma Immunol. 2011 Sep;10(3):147-54
pubmed: 21891820
Eplasty. 2008 Jun 10;8:e32
pubmed: 18615149
J Recept Signal Transduct Res. 2016 Oct;36(5):531-41
pubmed: 26895417
Int J Toxicol. 2014 Jul;33(4):271-281
pubmed: 24801489
Int Immunopharmacol. 2013 Nov;17(3):968-73
pubmed: 23375935
Toxicol Sci. 2015 Nov;148(1):71-88
pubmed: 26243812
Br J Ind Med. 1988 Oct;45(10):652-9
pubmed: 3196660
Lung. 2010 Jan-Feb;188(1):77-83
pubmed: 19862574
J Biochem Mol Toxicol. 2006;20(3):142-9
pubmed: 16788954
Inhal Toxicol. 2004 Jul;16(8):491-5
pubmed: 15204740
Arch Belg. 1984;Suppl:291-7
pubmed: 6535478
Toxicol Ind Health. 2016 Dec;32(12):1971-1977
pubmed: 26381687
Inhal Toxicol. 2011 Feb;23(3):157-65
pubmed: 21391784
Burns. 2007 Nov;33(7):923-6
pubmed: 17532574
Immunopharmacol Immunotoxicol. 2016 Aug;38(4):270-80
pubmed: 27241137
Inhal Toxicol. 2005 Oct;17(11):587-92
pubmed: 16033754
Int Immunopharmacol. 2012 May;13(1):101-8
pubmed: 22465472
Int Immunopharmacol. 2009 Dec;9(13-14):1477-81
pubmed: 19733695
J Am Acad Dermatol. 1995 May;32(5 Pt 1):765-76
pubmed: 7722023
Chem Biol Interact. 2013 Dec 5;206(3):512-22
pubmed: 23816402
Ecotoxicol Environ Saf. 2002 Nov;53(3):422-4
pubmed: 12485587
Toxicol Appl Pharmacol. 2011 Feb 1;250(3):245-55
pubmed: 21070800
Int J Chron Obstruct Pulmon Dis. 2010 Oct 05;5:335-40
pubmed: 21037957
J Cell Physiol. 2018 Apr;233(4):3037-3047
pubmed: 28667758
Pulm Pharmacol Ther. 2011 Feb;24(1):92-9
pubmed: 20851203
Cutan Ocul Toxicol. 2018 Dec;37(4):332-337
pubmed: 29648477
Toxicol Appl Pharmacol. 2009 Dec 1;241(2):154-62
pubmed: 19682477
Mutat Res Genet Toxicol Environ Mutagen. 2016 Apr;800-801:12-21
pubmed: 27085470
Immunopharmacol Immunotoxicol. 2018 Aug;40(4):290-296
pubmed: 29676192
J Interferon Cytokine Res. 2007 Jan;27(1):38-43
pubmed: 17266442
J Biochem Mol Toxicol. 2003;17(3):177-84
pubmed: 12815614
Inhal Toxicol. 2004 Jul;16(8):537-48
pubmed: 15204745
Toxicology. 2009 Sep 1;263(1):41-6
pubmed: 18852015
Hum Exp Toxicol. 2009 Dec;28(12):739-45
pubmed: 19919970
J Biochem Mol Toxicol. 2010 May-Jun;24(3):187-94
pubmed: 20583300
Occup Environ Med. 2017 May;74(5):321-327
pubmed: 27516111
Inhal Toxicol. 2009 Sep;21(11):958-64
pubmed: 19572781
Toxicol Sci. 2017 Jun 1;157(2):399-409
pubmed: 28402575
Biochem Genet. 2016 Dec;54(6):769-783
pubmed: 27484501
Immunopharmacol Immunotoxicol. 2018 Oct;40(5):359-367
pubmed: 30488735
Toxicol Appl Pharmacol. 2016 Aug 15;305:1-11
pubmed: 27212445
Expert Rev Clin Immunol. 2017 Dec;13(12):1173-1188
pubmed: 28994328
Exp Lung Res. 2016 May;42(4):217-26
pubmed: 27266564
Am J Respir Cell Mol Biol. 2016 Mar;54(3):436-46
pubmed: 26273949
Crit Rev Toxicol. 2012 Sep;42(8):688-702
pubmed: 22742653
Int J Clin Pharmacol Ther Toxicol. 1989 Sep;27(9):419-35
pubmed: 2681003
Toxicology. 2007 Oct 30;240(1-2):60-9
pubmed: 17720292
Hum Exp Toxicol. 2011 Sep;30(9):1141-9
pubmed: 21071549
Anal Chem. 2018 Jan 16;90(2):1417-1422
pubmed: 29300079
Cell J. 2017 Apr-Jun;19(1):117-126
pubmed: 28367422
J Toxicol. 2010;2010:373612
pubmed: 21317984
Respir Med. 2019 Apr;150:21-29
pubmed: 30961947
Mutat Res. 2009 Aug;678(1):1-6
pubmed: 19559099
J Biochem Mol Toxicol. 2009 Mar-Apr;23(2):143-53
pubmed: 19367648
J Biochem Mol Toxicol. 2017 May;31(5):
pubmed: 27900814
Toxicology. 2005 Oct 30;214(3):198-209
pubmed: 16084004
Cell Biol Toxicol. 1994 Aug;10(4):231-46
pubmed: 7895152
Am J Dermatopathol. 1998 Feb;20(1):22-8
pubmed: 9504665
Toxicol Appl Pharmacol. 2013 Oct 1;272(1):86-95
pubmed: 23727623
Toxicol Appl Pharmacol. 2012 May 15;261(1):22-30
pubmed: 22446026
Toxicol Sci. 2019 Apr 1;168(2):287-301
pubmed: 30590802
Basic Clin Pharmacol Toxicol. 2008 Nov;103(5):428-32
pubmed: 18801028
J Appl Toxicol. 2010 Oct;30(7):627-43
pubmed: 20836142
Fundam Clin Pharmacol. 2005 Jun;19(3):297-315
pubmed: 15910653
Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1160-4
pubmed: 15286001
Inhal Toxicol. 2007 Aug;19(10):889-94
pubmed: 17687719
Pharmacol Rev. 1996 Jun;48(2):289-326
pubmed: 8804107
Respir Med. 2008 Mar;102(3):443-8
pubmed: 18036807
Toxicology. 2012 Nov 15;301(1-3):66-71
pubmed: 22776411
Int Immunopharmacol. 2009 Dec;9(13-14):1489-93
pubmed: 19733694
Int Immunopharmacol. 2019 Aug;73:81-93
pubmed: 31082726
Toxicology. 2009 Sep 1;263(1):3-8
pubmed: 19482056
PLoS One. 2006 Dec 27;1:e108
pubmed: 17205112
Chem Res Toxicol. 2018 Apr 16;31(4):211-222
pubmed: 29569912
Chin J Traumatol. 2013;16(3):163-8
pubmed: 23735551
Antioxid Redox Signal. 2008 May;10(5):973-81
pubmed: 18257742
Int Immunopharmacol. 2013 Nov;17(3):958-63
pubmed: 23370297
Am J Epidemiol. 2011 Mar 15;173(6):659-66
pubmed: 21335423
Inhal Toxicol. 2014 Aug;26(9):507-23
pubmed: 25055840
Int Immunopharmacol. 2009 Dec;9(13-14):1466-70
pubmed: 19747989
J Appl Physiol (1985). 1994 Feb;76(2):681-8
pubmed: 8175578
Exp Mol Pathol. 2014 Aug;97(1):89-98
pubmed: 24886962
Environ Toxicol Pharmacol. 2016 Jul;45:187-92
pubmed: 27317991
Toxicology. 2011 Feb 27;280(3):88-97
pubmed: 21129433
Int J Epidemiol. 2004 Jun;33(3):579-81
pubmed: 15163642