Extracellular Vesicles in Modifying the Effects of Ionizing Radiation.
extracellular vesicles
intercellular signaling
ionizing radiation
nanocarriers
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Nov 2019
06 Nov 2019
Historique:
received:
08
09
2019
revised:
26
10
2019
accepted:
04
11
2019
entrez:
9
11
2019
pubmed:
9
11
2019
medline:
14
4
2020
Statut:
epublish
Résumé
Extracellular vesicles (EVs) are membrane-coated nanovesicles actively secreted by almost all cell types. EVs can travel long distances within the body, being finally taken up by the target cells, transferring information from one cell to another, thus influencing their behavior. The cargo of EVs comprises of nucleic acids, lipids, and proteins derived from the cell of origin, thereby it is cell-type specific; moreover, it differs between diseased and normal cells. Several studies have shown that EVs have a role in tumor formation and prognosis. It was also demonstrated that ionizing radiation can alter the cargo of EVs. EVs, in turn can modulate radiation responses and they play a role in radiation-induced bystander effects. Due to their biocompatibility and selective targeting, EVs are suitable nanocarrier candidates of drugs in various diseases, including cancer. Furthermore, the cargo of EVs can be engineered, and in this way they can be designed to carry certain genes or even drugs, similar to synthetic nanoparticles. In this review, we describe the biological characteristics of EVs, focusing on the recent efforts to use EVs as nanocarriers in oncology, the effects of EVs in radiation therapy, highlighting the possibilities to use EVs as nanocarriers to modulate radiation effects in clinical applications.
Identifiants
pubmed: 31698689
pii: ijms20225527
doi: 10.3390/ijms20225527
pmc: PMC6888126
pii:
doi:
Substances chimiques
Drug Carriers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Horizon 2020 Framework Programme
ID : Concert 662287
Organisme : the Hungarian National Research, Development and Innovation Office ( NKFI)
ID : NKFI-124879
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