Acute Liver Injury after CCl
Smad7
TGF-β
inflammation
liver injury
myeloid cell
regeneration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Nov 2019
06 Nov 2019
Historique:
received:
08
10
2019
revised:
29
10
2019
accepted:
04
11
2019
entrez:
9
11
2019
pubmed:
9
11
2019
medline:
14
4
2020
Statut:
epublish
Résumé
Myeloid cells are essential for the initiation and termination of innate and adaptive immunity that create homeostasis in the liver. Smad7 is an inhibitor of the transforming growth factor β (TGF-β) signaling pathway, which regulates inflammatory cellular processes. Knockdown of Smad7 in hepatocytes has been shown to promote liver fibrosis, but little is known about the effects of Smad7 in myeloid cells during inflammatory responses in the liver. Using mice with a myeloid-specific knockdown of Smad7 (LysM-Cre Smad7
Identifiants
pubmed: 31698731
pii: ijms20225528
doi: 10.3390/ijms20225528
pmc: PMC6888233
pii:
doi:
Substances chimiques
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB841 B1 & B9
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