aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions.
atypical PKC ι
cell extrusion
cell junction
cell segregation
vinculin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 11 2019
26 11 2019
Historique:
pubmed:
9
11
2019
medline:
23
4
2020
entrez:
9
11
2019
Statut:
ppublish
Résumé
Metastasis is the main cause of cancer-related deaths. How a single oncogenic cell evolves within highly organized epithelium is still unknown. Here, we found that the overexpression of the protein kinase atypical protein kinase C ι (aPKCi), an oncogene, triggers basally oriented epithelial cell extrusion in vivo as a potential mechanism for early breast tumor cell invasion. We found that cell segregation is the first step required for basal extrusion of luminal cells and identify aPKCi and vinculin as regulators of cell segregation. We propose that asymmetric vinculin levels at the junction between normal and aPKCi
Identifiants
pubmed: 31699818
pii: 1906779116
doi: 10.1073/pnas.1906779116
pmc: PMC6883778
doi:
Substances chimiques
Isoenzymes
0
Vinculin
125361-02-6
Protein Kinase C
EC 2.7.11.13
protein kinase C lambda
EC 2.7.11.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
24108-24114Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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