Leukocyte-rich PRP versus leukocyte-poor PRP
Macrophages
Mononuclear cells
Platelet rich plasma
Regeneration
Journal
Journal of clinical orthopaedics and trauma
ISSN: 0976-5662
Titre abrégé: J Clin Orthop Trauma
Pays: India
ID NLM: 101559469
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
11
02
2019
accepted:
09
05
2019
entrez:
9
11
2019
pubmed:
9
11
2019
medline:
9
11
2019
Statut:
ppublish
Résumé
The mechanism of action of Platelet Rich Plasma (PRP) is thought to be related to the biomolecules present in α-granules. However, for the healing process to occur, an inflammatory phase is also deemed necessary. Leukocytes present in the inflammatory phase release both pro- and anti-inflammatory molecules. The latter may play an important role in the process of "inflammatory regeneration". Thus, we propose that in the context of healing, both platelets and leukocytes play an important role, specifically due to the macrophage's plasticity to switch from the M1 to M2 fraction. Therefore, we propose that PRP products derived from the buffy coat may be more beneficial than detrimental from a standpoint of the regenerative potential of PRP.
Identifiants
pubmed: 31700202
doi: 10.1016/j.jcot.2019.05.008
pii: S0976-5662(19)30142-0
pmc: PMC6823808
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
S7-S12Informations de copyright
© 2019 Delhi Orthopedic Association. All rights reserved.
Références
Blood. 2014 May 1;123(18):2759-67
pubmed: 24585776
J Thromb Haemost. 2009 Jul;7 Suppl 1:173-6
pubmed: 19630794
PLoS One. 2014 Jan 22;9(1):e86660
pubmed: 24466192
J Leukoc Biol. 2006 Dec;80(6):1298-307
pubmed: 16905575
Immunobiology. 2006;211(6-8):473-86
pubmed: 16920487
J Exp Med. 1989 Dec 1;170(6):2081-95
pubmed: 2531194
J Biol Chem. 2004 Oct 22;279(43):44250-7
pubmed: 15308650
Vet Comp Orthop Traumatol. 2015;28(3):172-8
pubmed: 25804324
Theranostics. 2017 Jan 1;7(1):81-96
pubmed: 28042318
Platelets. 2013;24(1):63-70
pubmed: 22372532
J Thromb Haemost. 2014 May;12(5):614-27
pubmed: 24618123
PLoS One. 2010 Mar 22;5(3):e9753
pubmed: 20339534
Regen Med. 2017 Jul;12(5):565-574
pubmed: 28758836
Can J Cardiol. 2010 Apr;26(4):140-5
pubmed: 20386775
F1000Prime Rep. 2014 Mar 03;6:13
pubmed: 24669294
J Orthop Res. 2008 Mar;26(3):404-10
pubmed: 17960651
Semin Cell Dev Biol. 2002 Aug;13(4):293-302
pubmed: 12243729
Nat Rev Immunol. 2011 Oct 25;11(11):750-61
pubmed: 22025054
J Thromb Haemost. 2007 Oct;5(10):2009-16
pubmed: 17650077
J Immunol. 2002 Sep 1;169(5):2602-10
pubmed: 12193731
Curr Opin Lipidol. 2015 Oct;26(5):412-9
pubmed: 26309202
Arthroscopy. 2012 Mar;28(3):429-39
pubmed: 22284405
Nat Rev Genet. 2014 Aug;15(8):514
pubmed: 24958437
Am J Sports Med. 2012 Jun;40(6):1274-81
pubmed: 22495144
Stem Cell Res Ther. 2015 Sep 15;6:173
pubmed: 26373929
Regen Med. 2013 Sep;8(5):645-58
pubmed: 23998756
Med Clin North Am. 2016 Jan;100(1):199-217
pubmed: 26614728
Int Immunopharmacol. 2013 Dec;17(4):1176-84
pubmed: 23810443
Nat Rev Immunol. 2018 Jan;18(1):62-76
pubmed: 28853443
Thromb Res. 2012 Oct;130 Suppl 1:S98-9
pubmed: 23026678
Annu Rev Immunol. 2017 Apr 26;35:53-84
pubmed: 27912316
Am J Sports Med. 2011 Oct;39(10):2135-40
pubmed: 21846925
Br J Oral Maxillofac Surg. 2017 Sep;55(7):697-702
pubmed: 28622916
PLoS One. 2014 Jan 24;9(1):e87243
pubmed: 24475257
PLoS One. 2014 Feb 03;9(2):e87680
pubmed: 24498352
Blood Rev. 2014 Jul;28(4):155-66
pubmed: 24826991
Transfus Apher Sci. 2017 Apr;56(2):135-140
pubmed: 28029568
J Immunol. 2000 Jun 15;164(12):6166-73
pubmed: 10843666
Angiogenesis. 2014 Jan;17(1):109-18
pubmed: 24013945
Cell. 2008 Aug 8;134(3):496-507
pubmed: 18692472
Eur Cell Mater. 2014 Sep 22;28:137-51; discussion 151
pubmed: 25241964
PLoS Pathog. 2009 Apr;5(4):e1000371
pubmed: 19360123
Knee Surg Sports Traumatol Arthrosc. 2015 Sep;23(9):2690-703
pubmed: 24942296
Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):83-91
pubmed: 24015667
J Exp Med. 2006 May 15;203(5):1221-33
pubmed: 16618794
Thromb Haemost. 2004 Jan;91(1):4-15
pubmed: 14691563
Science. 2007 Aug 3;317(5838):666-70
pubmed: 17673663
Am J Sports Med. 2017 Jul;45(8):1909-1920
pubmed: 28301205
Int J Biochem Cell Biol. 2005 Jun;37(6):1162-7
pubmed: 15778080
Curr Pharm Biotechnol. 2012 Jun;13(7):1131-7
pubmed: 21740379