Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.
Medulloblastoma
Sonic hedgehog
cell senescence
tumor microenvironment
tumor progression
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2019
2019
Historique:
accepted:
23
10
2019
entrez:
9
11
2019
pubmed:
9
11
2019
medline:
4
6
2020
Statut:
epublish
Résumé
Medulloblastoma, the most common of the malignant pediatric brain tumors, is a group of four molecularly and clinically distinct cancers with different cells of origin. One of these medulloblastoma groups displays activation of Sonic hedgehog (SHH) signaling and originates from granule cell precursors of the developing cerebellum. Ongoing basic and clinical research efforts are tailored to discover targeted and safer therapies, which rely on the identification of the basic mechanisms regulating tumor initiation, progression, and metastasis. In SHH medulloblastoma, the mechanisms regulating neural progenitor transformation and progression to advanced tumors have been studied in some detail. The present review discusses recent advances on medulloblastoma progression derived from studies using mouse models of SHH medulloblastoma. We focus on mechanisms that regulate progression from precancerous lesions to medulloblastoma, describing novel roles played by tumor suppressor mechanisms and the tumor microenvironment.
Identifiants
pubmed: 31700613
doi: 10.12688/f1000research.20013.1
pmc: PMC6820827
pii:
doi:
Substances chimiques
Hedgehog Proteins
0
SHH protein, human
0
Shh protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : FDN334023
Pays : Canada
Informations de copyright
Copyright: © 2019 Tamayo-Orrego L and Charron F.
Déclaration de conflit d'intérêts
No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.
Références
Cell Cycle. 2016 Aug 17;15(16):2102-2107
pubmed: 27229128
Nature. 2019 Aug;572(7767):67-73
pubmed: 31043743
PLoS One. 2011;6(5):e20267
pubmed: 21647415
Cell. 2018 May 31;173(6):1549
pubmed: 29856958
Cancer Cell. 2017 Jun 12;31(6):737-754.e6
pubmed: 28609654
Nature. 2014 Jun 26;510(7506):537-41
pubmed: 24847876
Cell. 2016 Feb 25;164(5):1060-1072
pubmed: 26919435
BMC Cancer. 2018 May 8;18(1):535
pubmed: 29739450
Trends Genet. 1993 Apr;9(4):138-41
pubmed: 8516849
Nat Rev Mol Cell Biol. 2013 Jul;14(7):416-29
pubmed: 23719536
Nature. 2006 Nov 30;444(7119):638-42
pubmed: 17136094
Cancer Cell. 2004 Sep;6(3):229-40
pubmed: 15380514
Oncogene. 2010 Mar 25;29(12):1845-56
pubmed: 20062081
Science. 1997 Aug 22;277(5329):1109-13
pubmed: 9262482
Clin Cancer Res. 2015 Mar 15;21(6):1457-65
pubmed: 25344580
Biomark Res. 2013 Mar 01;1(1):14
pubmed: 24252239
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3458-66
pubmed: 25082897
Neurotoxicology. 1993 Spring;14(1):83-144
pubmed: 8361683
Nat Rev Cancer. 2012 Dec;12(12):818-34
pubmed: 23175120
Exp Neurol. 2014 Oct;260:69-73
pubmed: 23178582
Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8
pubmed: 20177397
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):111-6
pubmed: 16373498
Cell. 2016 Jan 14;164(1-2):156-169
pubmed: 26771489
Nat Neurosci. 2013 Dec;16(12):1737-44
pubmed: 24141309
Cancer Immunol Immunother. 2011 May;60(5):693-703
pubmed: 21327638
N Engl J Med. 1986 Dec 25;315(26):1650-9
pubmed: 3537791
Cancer Res. 2009 Jun 1;69(11):4682-90
pubmed: 19487286
Nature. 2018 Jan 4;553(7686):96-100
pubmed: 29258294
Neuron. 1999 Jan;22(1):103-14
pubmed: 10027293
Cell Cycle. 2010 Feb 1;9(3):570-79
pubmed: 20081366
Cancer Cell. 2014 Mar 17;25(3):393-405
pubmed: 24651015
Clin Cancer Res. 2016 Feb 1;22(3):582-95
pubmed: 26405194
Cancer Cell. 2008 Aug 12;14(2):135-45
pubmed: 18691548
Cancer Cell. 2007 Jan;11(1):69-82
pubmed: 17222791
Annu Rev Neurosci. 1995;18:385-408
pubmed: 7605067
PLoS One. 2008 Aug 28;3(8):e3088
pubmed: 18769486
PLoS One. 2015 Mar 20;10(3):e0120252
pubmed: 25794107
Dis Model Mech. 2013 Jan;6(1):49-63
pubmed: 23065639
Nature. 2017 Jul 19;547(7663):311-317
pubmed: 28726821
Cancer Cell. 2017 Mar 13;31(3):326-341
pubmed: 28292436
Nat Rev Cancer. 2001 Nov;1(2):157-62
pubmed: 11905807
Nature. 2012 Aug 2;488(7409):100-5
pubmed: 22832583
Genes Dev. 2008 Feb 15;22(4):436-48
pubmed: 18281460
Oncoimmunology. 2018 May 24;7(9):e1462430
pubmed: 30228931
PLoS One. 2015 Apr 22;10(4):e0124870
pubmed: 25901736
Oncogene. 2017 Nov 9;36(45):6306-6314
pubmed: 28714964
Cell. 1990 Jun 1;61(5):759-67
pubmed: 2188735
Cancer Cell. 2008 Aug 12;14(2):123-34
pubmed: 18691547
Mol Cell Biol. 2000 Dec;20(23):9055-67
pubmed: 11074003
Development. 2005 May;132(10):2425-39
pubmed: 15843415
Cancer Res. 2017 Jan 1;77(1):123-133
pubmed: 27815386
Annu Rev Cell Dev Biol. 2007;23:549-77
pubmed: 17506688
Acta Neuropathol. 2012 Apr;123(4):473-84
pubmed: 22358457
Nature. 2004 Mar 18;428(6980):337-41
pubmed: 15029199
Curr Biol. 1999 Apr 22;9(8):445-8
pubmed: 10226030
Cell Cycle. 2010 Nov 1;9(21):4307-14
pubmed: 21051932
Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7331-6
pubmed: 12777630
J Comp Neurol. 2009 Apr 10;513(5):532-41
pubmed: 19226510
Acta Neuropathol. 2012 Apr;123(4):465-72
pubmed: 22134537
Endocrinology. 2004 Aug;145(8):3961-70
pubmed: 15132968
Nat Commun. 2019 Jun 3;10(1):2410
pubmed: 31160587
J Neurosurg Pediatr. 2019 Feb 15;:1-9
pubmed: 30771762
Oncogene. 2014 Apr 10;33(15):1922-33
pubmed: 23728345
Cell Rep. 2016 Mar 29;14(12):2925-37
pubmed: 26997276
Genes Dev. 2009 Dec 1;23(23):2729-41
pubmed: 19952108
Nature. 2008 Sep 18;455(7211):406-10
pubmed: 18754008
Cancer Res. 2016 Sep 15;76(18):5573-83
pubmed: 27496710
Cancer Cell. 2014 Jul 14;26(1):33-47
pubmed: 24954133
N Engl J Med. 1988 Sep 1;319(9):525-32
pubmed: 2841597
J Thromb Haemost. 2014 Nov;12(11):1838-49
pubmed: 25163932
Oncogene. 2006 Sep 7;25(40):5575-80
pubmed: 16636673
Cancer Res. 2006 Oct 15;66(20):10171-8
pubmed: 17047082
Cancer Cell. 2009 Feb 3;15(2):135-47
pubmed: 19185848
Nat Neurosci. 2005 Jun;8(6):723-9
pubmed: 15908947
Neoplasia. 2008 Dec;10(12):1343-9, 5p following 1349
pubmed: 19048113
Cancer Res. 2018 Aug 15;78(16):4599-4612
pubmed: 29921697
Science. 2010 Mar 26;327(5973):1650-3
pubmed: 20339075
Annu Rev Physiol. 2013;75:685-705
pubmed: 23140366
Cancer Res. 2013 Jun 15;73(12):3796-807
pubmed: 23596255
Oncogene. 2012 Jan 12;31(2):187-99
pubmed: 21685941
Development. 1999 Jun;126(14):3089-100
pubmed: 10375501
Cancer Cell. 2013 Jan 14;23(1):23-34
pubmed: 23291299
Development. 2003 Jan;130(1):15-28
pubmed: 12441288
Nature. 2012 Aug 2;488(7409):106-10
pubmed: 22820256
Cancer Discov. 2016 Jun;6(6):584-93
pubmed: 27029895
Nat Neurosci. 2016 Jan;19(1):20-7
pubmed: 26713745
Dev Cell. 2008 Dec;15(6):801-12
pubmed: 19081070
Development. 2012 May;139(10):1724-33
pubmed: 22461560
Cancer Res. 2017 Dec 1;77(23):6692-6703
pubmed: 28986380
Neoplasia. 2014 Dec;16(12):993-1006
pubmed: 25499213
Cancer Cell. 2016 Apr 11;29(4):508-522
pubmed: 27050100
Development. 2016 Nov 1;143(21):4038-4052
pubmed: 27803059
Nat Cell Biol. 2019 Jan;21(1):94-101
pubmed: 30602768
Science. 2011 Dec 23;334(6063):1727-31
pubmed: 22144466
Nature. 2010 Dec 23;468(7327):1095-9
pubmed: 21150899
Cell. 2012 Jan 20;148(1-2):59-71
pubmed: 22265402
Science. 2016 Nov 25;354(6315):
pubmed: 27884981
Elife. 2016 Nov 08;5:
pubmed: 27823583
Clin Cancer Res. 2008 Oct 1;14(19):5995-6004
pubmed: 18829478
Genes Dev. 2017 Jan 15;31(2):172-183
pubmed: 28143833
Mol Cancer Res. 2009 Jan;7(1):33-40
pubmed: 19147535
Nature. 2012 Aug 2;488(7409):49-56
pubmed: 22832581