Safety and Efficacy of Rituximab and Cyclophosphamide in a Case of Resistant Acquired Hemophilia A in Course of Chronic Lymphocytic Leukemia.
acquired hemophilia
cyclophosphamide
factor viii inhibitor
immunosuppressive treatment
rituximab
steroids
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
12 Sep 2019
12 Sep 2019
Historique:
entrez:
9
11
2019
pubmed:
9
11
2019
medline:
9
11
2019
Statut:
epublish
Résumé
Acquired Hemophilia A (AHA) is a rare disease caused by anti-factor VIII autoantibodies. It is usually characterized by clinically significant bleeding at the onset and requires prompt hemostatic and immunosuppressive therapies. Due to its rarity and the lack of randomized trials, its treatment is a great challenge, especially in the relapse/refractory setting. This report presents the case of a patient diagnosed with chronic lymphocytic leukemia who developed a steroid-resistant AHA, successfully managed with aggressive immunosuppressive therapy.
Identifiants
pubmed: 31700733
doi: 10.7759/cureus.5630
pmc: PMC6822901
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e5630Informations de copyright
Copyright © 2019, Mazziotta et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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