Proposed Therapeutic Range of Treosulfan in Reduced Toxicity Pediatric Allogeneic Hematopoietic Stem Cell Transplant Conditioning: Results From a Prospective Trial.
Adolescent
Busulfan
/ administration & dosage
Child
Child, Preschool
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Monitoring
England
Female
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Infant
Infant, Newborn
Infusions, Intravenous
Male
Models, Biological
Myeloablative Agonists
/ administration & dosage
Prospective Studies
Transplantation Conditioning
/ adverse effects
Transplantation, Homologous
Treatment Outcome
Vidarabine
/ administration & dosage
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
07
08
2019
accepted:
28
10
2019
pubmed:
9
11
2019
medline:
25
5
2021
entrez:
9
11
2019
Statut:
ppublish
Résumé
Treosulfan is given off-label in pediatric allogeneic hematopoietic stem cell transplant. This study investigated treosulfan's pharmacokinetics (PKs), efficacy, and safety in a prospective trial. Pediatric patients (n = 87) receiving treosulfan-fludarabine conditioning were followed for at least 1 year posttransplant. PKs were described with a two-compartment model. During follow-up, 11 of 87 patients died and 12 of 87 patients had low engraftment (≤ 20% myeloid chimerism). For each increase in treosulfan area under the curve from zero to infinity (AUC
Identifiants
pubmed: 31701524
doi: 10.1002/cpt.1715
pmc: PMC7484914
doi:
Substances chimiques
Myeloablative Agonists
0
treosulfan
CO61ER3EPI
Vidarabine
FA2DM6879K
Busulfan
G1LN9045DK
fludarabine
P2K93U8740
Types de publication
Clinical Trial, Phase II
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
264-273Subventions
Organisme : Medical Research Council
ID : MR/P014534/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008665/1
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.
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