ROS-Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide-Containing Recombinant Apoferritin.
Fe(II)-dependent drug
H-apoferritin
cancer therapy
iron mineralization
reactive oxygen species
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
11
07
2019
revised:
23
10
2019
pubmed:
9
11
2019
medline:
1
9
2020
entrez:
9
11
2019
Statut:
ppublish
Résumé
Reactive oxygen species (ROS)-mediated apoptosis is considered a crucial therapeutic mechanisms for artesunate (AS). As an Fe(II)-dependent drug, the anticancer effect of AS is often limited due to insufficient Fe(II) concentration in targeted cells. To overcome this problem, a recombinant apoferritin nanocarrier containing ferriferous oxide (M-HFn) is constructed to produce auxiliary exogenous Fe(II) when delivering AS to cancer cells. Here, the newly fabricated AS-loaded M-HFn nanoparticles (M-HFn@AS NPs) can significantly improve the tumor-specific targeting and intracellular uptake efficiency of AS in human cervical carcinoma cells. After being captured in the acidic cavity of endosomes, M-HFn@AS NPs can simultaneously release Fe(II) and allow AS to activate satisfactory ROS-mediated apoptosis. Furthermore, in vivo studies demonstrate that M-HFn@AS NPs can selectively accumulate in tumors to efficiently inhibit tumor growth. Thus, M-HFn@AS NPs are a promising system to enhance the therapeutic effect of Fe(II)-dependent drugs.
Identifiants
pubmed: 31701665
doi: 10.1002/adhm.201900911
doi:
Substances chimiques
Reactive Oxygen Species
0
Artesunate
60W3249T9M
Apoferritins
9013-31-4
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900911Subventions
Organisme : National Natural Science Foundation of China
ID : 51472115
Pays : International
Organisme : Top-notch Academic Programs Project of Jiangsu Higher Education Institutions
ID : PPZY2015B164
Pays : International
Organisme : China Pharmaceutical University
ID : CPU2018GY40
Pays : International
Organisme : Jiangsu Provincial Graduate Research Innovation and Practice Project
ID : KYCX18_0760
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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