Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
05
2019
accepted:
23
10
2019
entrez:
9
11
2019
pubmed:
9
11
2019
medline:
25
3
2020
Statut:
epublish
Résumé
Gene-environment interactions contribute to the risk for Autism Spectrum Disorder (ASD). Among environmental factors, prenatal exposure to stress may increase the risk for ASD. To examine if there is an interaction between exposure to maternal stress and reduced dosage or loss of Shank3, wild-type (WT), heterozygous (HET) and homozygous (HOM) female mice carrying a deletion of exons four through nine of Shank3 (Shank3ex4-9) were exposed to chronic unpredictable mild stress (CUMS) from prior to conception throughout gestation. This study examined maternal care of these dams and the white matter microstructure in the brains of their adult male offspring. Overall, our findings suggest that maternal exposure to CUMS increased pup-directed care for dams of all three genotypes. Compared to WT and HET dams, HOM dams also exhibited increased maternal care behaviors with increased time spent in the nest and reduced cage exploration, regardless of exposure to CUMS. Diffusion tensor imaging showed higher mean fractional anisotropy in the hippocampal stratum radiatum of WT and HOM male offspring from dams exposed to CUMS and HOM offspring from unexposed dams, compared to WT male offspring from unexposed dams. These data support that CUMS in Shank3-mutant dams results in subtle maternal care alterations and long-lasting changes in the white matter of the hippocampus of their offspring.
Identifiants
pubmed: 31703095
doi: 10.1371/journal.pone.0224876
pii: PONE-D-19-15139
pmc: PMC6839842
doi:
Substances chimiques
Microfilament Proteins
0
Nerve Tissue Proteins
0
Shank3 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0224876Subventions
Organisme : NCRR NIH HHS
ID : C06 RR029965
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008280
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008307
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083092
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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