Genetically Determined Physical Activity and Its Association with Circulating Blood Cells.
blood cell counts
inflammation
physical activity
single nucleotide polymorphisms
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
07 11 2019
07 11 2019
Historique:
received:
18
09
2019
revised:
04
11
2019
accepted:
05
11
2019
entrez:
10
11
2019
pubmed:
11
11
2019
medline:
13
3
2020
Statut:
epublish
Résumé
Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemic inflammation, in which circulating blood cells play a pivotal role. In this study we investigated the relationship between genetically determined PA and circulating blood cells. We used 68 single nucleotide polymorphisms associated with objectively measured PA levels to perform a Mendelian randomization analysis on circulating blood cells in 222,645 participants of the UK Biobank. For inverse variance fixed effects Mendelian randomization analyses,
Identifiants
pubmed: 31703460
pii: genes10110908
doi: 10.3390/genes10110908
pmc: PMC6895919
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
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