Pain therapy - Are there new options on the horizon?

Analgesics, Opioid / adverse effects Chronic Pain / drug therapy Humans Pain Management / methods
Abuse Bio-psycho-social Chronic noncancer pain Chronic nonmalignant pain Inflammation Misuse Opiate Opioid Opioid crisis Opioid receptor

Journal

Best practice & research. Clinical rheumatology
ISSN: 1532-1770
Titre abrégé: Best Pract Res Clin Rheumatol
Pays: Netherlands
ID NLM: 101121149

Informations de publication

Date de publication:
06 2019
Historique:
entrez: 10 11 2019
pubmed: 11 11 2019
medline: 6 2 2020
Statut: ppublish

Résumé

This article reviews the role of analgesic drugs with a particular emphasis on opioids. Opioids are the oldest and most potent drugs for the treatment of severe pain, but they are burdened by detrimental side effects such as respiratory depression, addiction, sedation, nausea, and constipation. Their clinical application is undisputed in acute (e.g., perioperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutiny and has contributed to the current opioid crisis. We discuss epidemiological data, pharmacological principles, clinical applications, and research strategies aiming at novel opioids with reduced side effects.

Identifiants

DOI: 10.1016/j.berh.2019.06.002 PMID: 31703793
pubmed: 31703793
pii: S1521-6942(19)30089-0
doi: 10.1016/j.berh.2019.06.002
pii:
doi:

Substances chimiques

Analgesics, Opioid 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101420

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Christoph Stein (C)

Department of Experimental Anesthesiology, Charité Campus Benjamin Franklin, D-12200 Berlin, Germany. Electronic address: Christoph.Stein@charite.de.

Andreas Kopf (A)

Department of Anesthesiology and Intensive Care Medicine, Charité Campus Benjamin Franklin, D-12200 Berlin, Germany.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Pain therapy - Are there new options on the horizon?
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Pain therapy - Are there new options on the horizon?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pain therapy - Are there new options on the horizon?
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Gestion de la douleur › Pain therapy - Are there new options on the horizon?