Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems.
antisense therapy
drug delivery
gene therapy
gold nanoparticles
immunomodulation
spherical nucleic acids
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
12
2018
revised:
26
08
2019
accepted:
28
08
2019
pubmed:
11
11
2019
medline:
22
7
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
Spherical nucleic acids (SNAs) are nanostructures consisting of highly oriented, dense layers of oligonucleotides arranged in a spherical 3D geometry. Owing to their unique properties and function, SNAs occupy a material space distinct from 'DNA nanotechnology' and DNA origami. Over the past two decades SNAs have revolutionized gene regulation, drug delivery, gene therapy, and molecular diagnostics, and show promise for both antisense and RNAi therapy. We focus here on recent advances in the synthesis and application of SNAs in gene and drug delivery, diagnostics, and immunomodulation, as well as on the utility of nanoflares as intracellular mRNA detection systems.
Identifiants
pubmed: 31703931
pii: S1471-4914(19)30235-7
doi: 10.1016/j.molmed.2019.08.012
pii:
doi:
Substances chimiques
Nucleic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1066-1079Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.