Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the rat.
Animals
Behavior, Animal
/ drug effects
Cognition
/ drug effects
Diazinon
/ administration & dosage
Female
Insecticides
/ administration & dosage
Male
Maze Learning
/ drug effects
Pregnancy
Prenatal Exposure Delayed Effects
/ physiopathology
Rats
Rats, Sprague-Dawley
Recognition, Psychology
/ drug effects
Behavioral teratogenesis
Development
Diazinon
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
18
06
2019
revised:
16
09
2019
accepted:
30
10
2019
pubmed:
11
11
2019
medline:
18
8
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
Diazinon is a widely-used organophosphate pesticide. Pulsatile exposure to diazinon during neonatal development has previously been shown cause long-term neurobehavioral impairments in rats. However, the effects of chronic low concentration exposures during perinatal development remain unclear. This experiment evaluated such effects in Sprague-Dawley rats by implanting osmotic pumps in breeder females prior to conception (N = 13-15 litters per condition) which then delivered chronic, zero order kinetic low-level infusions of 0, 114 or 228 ug/day of diazinon throughout pregnancy. One male and one female from each litter was assessed with a battery of behavioral tests that continued from four weeks of age into adulthood. Litter was used as the unit of variance for the analysis of variance test of significance, with sex as a within litter factor. Diazinon treatment condition was the between subjects factor and time or sessions were repeated measures. Chronic diazinon exposure from pre-mating until the neonatal period caused a significant (p < 0.05) increase in percent of time spent on the open arms of the elevated plus maze, an index of risk-taking behavior. Gestational and lactational diazinon exposure also caused a significant (p < 0.05) degree of hyperactivity in the Figure-8 apparatus during adolescence, specifically affecting the early part of the hour-long test session. This effect had dissipated by the time the rats reached adulthood. Diazinon exposure also caused a significant impairment in novel object recognition, a test of cognitive function. Offspring exposed to 228 ug/day diazinon (p < 0.05) showed significantly less preference for the novel vs. familiar object than controls during the first five minutes of the novel object recognition test.
Identifiants
pubmed: 31704166
pii: S0300-483X(19)30284-7
doi: 10.1016/j.tox.2019.152327
pmc: PMC6925319
mid: NIHMS1542841
pii:
doi:
Substances chimiques
Insecticides
0
Diazinon
YUS1M1Q929
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
152327Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES010356
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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