Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma.
Allergic sensitization
Asthma
Atopy
Cohort study
Epidemiology
IgE
Inhaled corticosteroids
Lung function decline
Precision medicine
Response to corticosteroids
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
16
05
2019
revised:
15
10
2019
accepted:
15
10
2019
pubmed:
11
11
2019
medline:
15
5
2021
entrez:
10
11
2019
Statut:
ppublish
Résumé
Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV FEV Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings.
Sections du résumé
BACKGROUND
Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few.
OBJECTIVE
To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma.
METHODS
We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV
RESULTS
FEV
CONCLUSIONS
Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings.
Identifiants
pubmed: 31704441
pii: S2213-2198(19)30914-6
doi: 10.1016/j.jaip.2019.10.023
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Clinical Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
980-988.e10Subventions
Organisme : Wellcome Trust
ID : WT 084703MA
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901214
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL056633
Pays : United States
Organisme : Medical Research Council
ID : 92091
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.