CoA Synthase (
Adenocarcinoma
/ genetics
Animals
Biomarkers, Tumor
/ analysis
Biopsy
Cell Line, Tumor
Cell Survival
/ genetics
DNA Repair
/ radiation effects
Female
Gene Knockdown Techniques
Humans
Male
Mice
Middle Aged
Neoadjuvant Therapy
/ methods
Phosphorylation
Proctectomy
Prospective Studies
RNA, Messenger
/ metabolism
RNA, Small Interfering
/ metabolism
Radiation Tolerance
/ genetics
Rectal Neoplasms
/ genetics
Rectum
/ pathology
Signal Transduction
/ genetics
Survival Analysis
Transferases
/ analysis
Treatment Outcome
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
17
04
2019
revised:
11
09
2019
accepted:
05
11
2019
pubmed:
11
11
2019
medline:
20
6
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
Neoadjuvant radiation is standard of care for locally advanced rectal cancer. Response to radiation is highly variable and directly linked with survival. However, there currently are no validated biomarkers or molecular targets to predict or improve radiation response, which would help develop personalized treatment and ideally targeted therapies. Here, we identified a novel biomarker, coenzyme A synthase (COASY), whose mRNA expression was consistently elevated in radioresistant human rectal cancers. This observation was validated in independent patient cohorts and further confirmed in colorectal cancer cell lines. Importantly, genetic overexpression and knockdown yielded radioresistant and sensitive phenotypes, respectively,
Identifiants
pubmed: 31704889
pii: 0008-5472.CAN-19-1161
doi: 10.1158/0008-5472.CAN-19-1161
pmc: PMC7050829
mid: NIHMS1542743
doi:
Substances chimiques
Biomarkers, Tumor
0
RNA, Messenger
0
RNA, Small Interfering
0
Transferases
EC 2.-
COASY protein, human
EC 2.7.7.3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
334-346Subventions
Organisme : NCI NIH HHS
ID : R01 CA193359
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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