The many functions of ESCRTs.
Animals
Cell Membrane
/ metabolism
Cytokinesis
Endosomal Sorting Complexes Required for Transport
/ metabolism
Endosomes
/ metabolism
Exosomes
/ metabolism
Host-Pathogen Interactions
Humans
Neurons
/ cytology
Nuclear Envelope
/ metabolism
Phagosomes
/ metabolism
Protein Transport
Spastin
/ metabolism
Virus Replication
/ physiology
Journal
Nature reviews. Molecular cell biology
ISSN: 1471-0080
Titre abrégé: Nat Rev Mol Cell Biol
Pays: England
ID NLM: 100962782
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
accepted:
13
09
2019
pubmed:
11
11
2019
medline:
10
5
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
Cellular membranes can form two principally different involutions, which either exclude or contain cytosol. The 'classical' budding reactions, such as those occurring during endocytosis or formation of exocytic vesicles, involve proteins that assemble on the cytosol-excluding face of the bud neck. Inverse membrane involution occurs in a wide range of cellular processes, supporting cytokinesis, endosome maturation, autophagy, membrane repair and many other processes. Such inverse membrane remodelling is mediated by a heteromultimeric protein machinery known as endosomal sorting complex required for transport (ESCRT). ESCRT proteins assemble on the cytosolic (or nucleoplasmic) face of the neck of the forming involution and cooperate with the ATPase VPS4 to drive membrane scission or sealing. Here, we review similarities and differences of various ESCRT-dependent processes, with special emphasis on mechanisms of ESCRT recruitment.
Identifiants
pubmed: 31705132
doi: 10.1038/s41580-019-0177-4
pii: 10.1038/s41580-019-0177-4
doi:
Substances chimiques
Endosomal Sorting Complexes Required for Transport
0
Spastin
EC 3.6.4.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-42Références
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