HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies.
Animals
Antineoplastic Agents
/ pharmacology
Autophagy
/ drug effects
Breast Neoplasms
/ drug therapy
Cell Line, Tumor
Drug Evaluation, Preclinical
Drug Resistance, Neoplasm
Female
Heme Oxygenase-1
/ metabolism
Humans
Lapatinib
/ pharmacology
Membrane Proteins
/ metabolism
Mice
Mice, Transgenic
Molecular Targeted Therapy
Protein Kinase Inhibitors
/ pharmacology
Quinazolines
/ pharmacology
Receptor, ErbB-2
/ antagonists & inhibitors
Autophagy
Breast cancer
HER2
HO-1
Resistance
Journal
Breast cancer research and treatment
ISSN: 1573-7217
Titre abrégé: Breast Cancer Res Treat
Pays: Netherlands
ID NLM: 8111104
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
03
05
2019
accepted:
29
10
2019
pubmed:
11
11
2019
medline:
4
9
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
Targeted therapies have resulted in major advances in the treatment of HER2-positive breast cancers. Despite this, up to 70% of patients will develop resistance to treatment within 2 years and new strategies for targeting resistant disease are needed. To identify potential resistance mechanisms, we used the mouse MMTV-NIC-PTEN Treatment of tumor-bearing MMTV-NIC-PTEN Together these data indicate a role for HO-1-induced autophagy in resistance to pan-HER family kinase inhibitors.
Identifiants
pubmed: 31705351
doi: 10.1007/s10549-019-05489-1
pii: 10.1007/s10549-019-05489-1
pmc: PMC6997276
doi:
Substances chimiques
AZD 8931
0
Antineoplastic Agents
0
Membrane Proteins
0
Protein Kinase Inhibitors
0
Quinazolines
0
Lapatinib
0VUA21238F
Heme Oxygenase-1
EC 1.14.14.18
Hmox1 protein, mouse
EC 1.14.14.18
ERBB2 protein, human
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-555Subventions
Organisme : Cancer Research UK
ID : C157/A15703
Pays : United Kingdom
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