Multiple esophageal ulcers due to tofacitinib 10 mg twice daily for ulcerative colitis.
Esophageal ulcers
Janus kinase inhibitor
Tofacitinib
Ulcerative colitis
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
05
09
2019
accepted:
24
10
2019
pubmed:
11
11
2019
medline:
18
3
2021
entrez:
10
11
2019
Statut:
ppublish
Résumé
A 26-year-old man was admitted to our institution for ulcerative colitis treatment. He used mesalamine, steroid, immunomodulators, and anti-TNFα anti-body, but it was difficult to maintain remission. We started induction therapy with tofacitinib (TOF) 10 mg twice daily. He maintained clinical remission but had chest pain 44 days after the start of TOF. Esophagogastroduodenoscopy showed multiple ulcers from middle to lower esophagus. Although rare, TOF induced esophageal ulcers were considered based on his clinical course and endoscopic findings.
Identifiants
pubmed: 31705375
doi: 10.1007/s12328-019-01061-y
pii: 10.1007/s12328-019-01061-y
doi:
Substances chimiques
Piperidines
0
Protein Kinase Inhibitors
0
Pyrimidines
0
tofacitinib
87LA6FU830
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM