Nonsteroidal Antiinflammatory Drugs as Potential Disease-Modifying Medications in Axial Spondyloarthritis.
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
29
05
2019
accepted:
07
11
2019
pubmed:
11
11
2019
medline:
21
7
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
Nonsteroidal antiinflammatory drugs (NSAIDs) are the first-line pharmacotherapy for patients with axial spondyloarthritis (SpA). In recent years, treatment options have expanded with the availability of biologic agents, including tumor necrosis factor inhibitors and interleukin-17 inhibitors. However, a treatment strategy that clearly prevents syndesmophyte formation has not been established. Observational studies of patients with ankylosing spondylitis indicated potential disease-modifying effects of NSAIDs, but two randomized trials came to different conclusions. More broadly, whether any of the currently available medications for axial SpA have an effect on spine radiographic progression, beyond symptom control, remains inconclusive. In this article, we will review clinical studies of the disease modification effects of NSAIDs and biologics in axial SpA; examine genetic, animal, and clinical evidence of the effects of NSAIDs on bone formation; and discuss how future studies may investigate the question of disease modification in axial SpA.
Identifiants
pubmed: 31705611
doi: 10.1002/art.41164
pmc: PMC7113090
mid: NIHMS1059215
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Antirheumatic Agents
0
Biological Products
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
518-528Subventions
Organisme : Intramural NIH HHS
ID : ZIA AR041153-14
Pays : United States
Informations de copyright
© 2019, American College of Rheumatology.
Références
Ann Rheum Dis. 2018 Feb;77(2):293-299
pubmed: 29127092
J Biomed Mater Res A. 2005 Mar 1;72(3):279-87
pubmed: 15666361
Arthritis Rheum. 2009 Jan;60(1):93-102
pubmed: 19116919
Ann Rheum Dis. 2019 Nov;78(11):1545-1549
pubmed: 31362994
Bone Joint J. 2018 Jul;100-B(7):915-922
pubmed: 29954195
J Rheumatol. 2018 Dec;45(12):1643-1650
pubmed: 29961689
Arthritis Rheum. 2004 Aug;50(8):2622-32
pubmed: 15334477
Arthritis Rheum. 2012 May;64(5):1388-98
pubmed: 22127957
Ann Rheum Dis. 2009 Jun;68 Suppl 2:ii1-44
pubmed: 19433414
Ann Rheum Dis. 2006 Dec;65(12):1572-7
pubmed: 16968715
Arthritis Rheum. 2006 Jul;54(7):2136-46
pubmed: 16802350
J Bone Miner Res. 2002 Feb;17(2):210-20
pubmed: 11811551
Blood. 1998 Mar 1;91(5):1769-76
pubmed: 9473245
Ann Rheum Dis. 2011 Feb;70(2):249-51
pubmed: 20829199
Rheumatology (Oxford). 2017 Jan;56(1):95-102
pubmed: 27997346
Arthritis Rheum. 2001 Sep;44(9):2078-83
pubmed: 11592370
Ann Rheum Dis. 2012 Oct;71(10):1616-22
pubmed: 22459541
Bone. 1997 Jun;20(6):521-6
pubmed: 9177865
Ann Rheum Dis. 2007 Jul;66(7):910-5
pubmed: 17329306
Ann Rheum Dis. 2004 Dec;63(12):1601-4
pubmed: 15297280
Ann Rheum Dis. 2012 Oct;71(10):1623-9
pubmed: 22532639
J Orthop Trauma. 2005 Nov-Dec;19(10):717-23
pubmed: 16314720
J Orthop Surg Res. 2018 Mar 5;13(1):48
pubmed: 29506541
J Periodontol. 1998 Jun;69(6):670-7
pubmed: 9660336
Ann Rheum Dis. 2014 Jan;73(1):101-7
pubmed: 23696633
J Am Acad Orthop Surg. 2019 Apr 1;27(7):e330-e336
pubmed: 30260913
J Biomech. 2000 Jan;33(1):53-61
pubmed: 10609518
Ann Rheum Dis. 2018 Mar;77(3):371-377
pubmed: 29127093
Ann Rheum Dis. 2014 Mar;73(3):544-50
pubmed: 23345598
J Bone Miner Res. 2002 Jun;17(6):963-76
pubmed: 12054171
Rheumatology (Oxford). 2015 Jun;54(6):972-80
pubmed: 25394620
Rheumatology (Oxford). 2019 May 1;58(5):859-868
pubmed: 30590813
Rheumatology (Oxford). 2014 Sep;53(9):1595-603
pubmed: 24706990
J Immunol. 2002 May 15;168(10):5310-7
pubmed: 11994489
J Endocrinol. 1998 Jan;156(1):51-7
pubmed: 9496233
Scand J Rheumatol. 1976;5(1):60-4
pubmed: 816001
Ann Rheum Dis. 2014 Jun;73(6):1107-13
pubmed: 23644549
J Orthop Trauma. 1995;9(5):392-400
pubmed: 8537842
Ann Rheum Dis. 2015 Jul;74(7):1387-93
pubmed: 24651623
Annu Rev Biochem. 2000;69:145-82
pubmed: 10966456
J Bone Joint Surg Am. 2007 Jan;89(1):114-25
pubmed: 17200318
Arthritis Rheum. 2013 Oct;65(10):2645-54
pubmed: 23818109
Arthritis Rheum. 2005 Jun;52(6):1756-65
pubmed: 15934081
Arthritis Res Ther. 2018 Oct 16;20(1):231
pubmed: 30326956
N Engl J Med. 2016 Jun 30;374(26):2563-74
pubmed: 27355535
J Rheumatol. 2018 Feb;45(2):188-194
pubmed: 29196383
J Orthop Res. 2002 Nov;20(6):1164-9
pubmed: 12472224
J Clin Invest. 1999 May;103(9):1345-52
pubmed: 10225978
Clin Rheumatol. 2018 Nov;37(11):3093-3098
pubmed: 29995219
Calcif Tissue Int. 2010 Sep;87(3):193-202
pubmed: 20552333
Ann Rheum Dis. 2015 Feb;74(2):437-43
pubmed: 24297375
Arthritis Rheum. 2008 Oct;58(10):3063-70
pubmed: 18821688
Calcif Tissue Int. 2000 Sep;67(3):241-6
pubmed: 10954779
J Periodontal Res. 2006 Apr;41(2):92-100
pubmed: 16499711
J Biol Chem. 2000 Jun 30;275(26):19819-23
pubmed: 10749873
Arthritis Rheum. 2008 Jun 15;59(6):822-32
pubmed: 18512723
Medicine (Baltimore). 2017 Aug;96(33):e7854
pubmed: 28816988
Arthritis Res Ther. 2017 May 2;19(1):83
pubmed: 28464949
Bone. 2002 Apr;30(4):567-73
pubmed: 11934647
Ann Rheum Dis. 2012 Apr;71(4):518-23
pubmed: 21989544
Ann Rheum Dis. 2014 Feb;73(2):437-45
pubmed: 23921997
Ann Rheum Dis. 2017 Jun;76(6):1070-1077
pubmed: 27965257
Ann Rheum Dis. 2015 Apr;74(4):746-51
pubmed: 24389295
Arthritis Res Ther. 2019 Jun 7;21(1):142
pubmed: 31174584
Arthritis Res Ther. 2017 Jun 15;19(1):140
pubmed: 28619118
Ann Rheum Dis. 2005 Oct;64(10):1462-6
pubmed: 15778240
Ann Rheum Dis. 2018 Jan;77(1):63-69
pubmed: 28939631
Ann Rheum Dis. 2014 Aug;73(8):1455-61
pubmed: 24812292
J Bone Miner Res. 1998 Jul;13(7):1066-75
pubmed: 9661070
Arthritis Res Ther. 2018 Aug 3;20(1):162
pubmed: 30075808
Arthritis Care Res (Hoboken). 2012 Jun;64(6):905-10
pubmed: 22275150
J Rheumatol. 2017 Jul;44(7):1004-1010
pubmed: 28507186
RMD Open. 2015 Sep 14;1(1):e000153
pubmed: 26535153
Ann Rheum Dis. 2016 Aug;75(8):1438-43
pubmed: 26242443
Arthritis Rheum. 2008 May;58(5):1324-31
pubmed: 18438853
J Orthop Res. 2003 Jul;21(4):670-5
pubmed: 12798067
Arthritis Care Res (Hoboken). 2019 Oct;71(10):1285-1299
pubmed: 31436026
Ann Rheum Dis. 2014 Oct;73(10):1819-25
pubmed: 23852807
Arch Orthop Trauma Surg. 2003 Sep;123(7):327-32
pubmed: 12811581
J Clin Invest. 2002 Jun;109(11):1405-15
pubmed: 12045254
Arch Orthop Trauma Surg. 2007 Jan;127(1):3-9
pubmed: 16865399
Ann Rheum Dis. 2015 Jan;74(1):52-9
pubmed: 23956249
Ann Rheum Dis. 2005 Jan;64(1):127-9
pubmed: 15051621
Ann Rheum Dis. 2018 May;77(5):699-705
pubmed: 29343510
Arthritis Res Ther. 2009;11(4):R127
pubmed: 19703304