How do elevated levels of testosterone affect the function of the human fallopian tube and fertility?-New insights.
Adult
Cervix Mucus
Cilia
/ enzymology
Fallopian Tube Diseases
/ chemically induced
Fallopian Tubes
/ drug effects
Female
Fertility
/ drug effects
Humans
Hysterectomy
Male
Middle Aged
Ovariectomy
Polycystic Ovary Syndrome
/ pathology
Receptors, Androgen
/ metabolism
Spermatozoa
/ drug effects
Testosterone
/ administration & dosage
Transgender Persons
Young Adult
PCOS
fallopian tube
human
hyperandrogenism
testosterone
transsexual
Journal
Molecular reproduction and development
ISSN: 1098-2795
Titre abrégé: Mol Reprod Dev
Pays: United States
ID NLM: 8903333
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
20
12
2018
accepted:
14
10
2019
pubmed:
11
11
2019
medline:
9
2
2021
entrez:
10
11
2019
Statut:
ppublish
Résumé
Excess testosterone levels affect up to 20% of the female population worldwide and are a key component in the pathogenesis of polycystic ovary syndrome. However, little is known about how excess testosterone affects the function of the human fallopian tube-the site of gamete transport, fertilization, and early embryogenesis. Therefore, this study aimed to characterize alterations caused by long-term exposure to male testosterone levels. For this purpose, the Fallopian tubes of nine female-to-male transsexuals, who had been undergoing testosterone treatment for 1-3 years, were compared with the tubes of 19 cycling patients. In the ampulla, testosterone treatment resulted in extensive luminal accumulations of secretions and cell debris which caused ciliary clumping and luminal blockage. Additionally, the percentage of ciliated cells in the ampulla was significantly increased. Transsexual patients, who had had sexual intercourse before surgery, showed spermatozoa trapped in mucus. Finally, in the isthmus complete luminal collapse occurred. Our results imply that fertility in women with elevated levels of testosterone is altered by tubal luminal obstruction resulting in impaired gamete transport and survival.
Substances chimiques
Receptors, Androgen
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-44Informations de copyright
© 2019 Wiley Periodicals, Inc.
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