Suppression of glycogen synthase expression reduces glycogen and lipid storage during mosquito overwintering diapause.
Journal
Journal of insect physiology
ISSN: 1879-1611
Titre abrégé: J Insect Physiol
Pays: England
ID NLM: 2985080R
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
17
05
2019
revised:
04
11
2019
accepted:
04
11
2019
pubmed:
11
11
2019
medline:
30
12
2020
entrez:
10
11
2019
Statut:
ppublish
Résumé
During diapause in mosquitoes, efficient storage and utilization of energy are crucial for surviving prolonged periods of developmental arrest and for maximizing reproductive success once diapause is terminated and development recommences. In Culex pipiens, glycogen rapidly accumulates during early diapause (7-10 days after adult eclosion) and it is used to maintain energy homeostasis during the first month of diapause. In this study, a gene encoding glycogen synthase, which converts glucose residues into a polymeric chain for storage as glycogen, was characterized. After dsi-RNA directed against glycogen synthase was injected into mosquitoes programmed for diapause (reared under short day lengths), Cx. pipiens were fed 1% d-[
Identifiants
pubmed: 31705845
pii: S0022-1910(19)30190-8
doi: 10.1016/j.jinsphys.2019.103971
pmc: PMC7266145
mid: NIHMS1592561
pii:
doi:
Substances chimiques
Insect Proteins
0
Glycogen
9005-79-2
Glycogen Synthase
EC 2.4.1.11
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
103971Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM116130
Pays : United States
Organisme : NIAID NIH HHS
ID : R15 AI139861
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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