Human Olfaction without Apparent Olfactory Bulbs.
anosmia
brain plasticity
functional brain imaging
left-handedness
odor coding
olfaction
olfactory bulb
olfactory perception
structural brain imaging
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
08 01 2020
08 01 2020
Historique:
received:
22
04
2019
revised:
16
07
2019
accepted:
01
10
2019
pubmed:
11
11
2019
medline:
31
3
2020
entrez:
11
11
2019
Statut:
ppublish
Résumé
The olfactory bulbs (OBs) are the first site of odor representation in the mammalian brain, and their unique ultrastructure is considered a necessary substrate for spatiotemporal coding of smell. Given this, we were struck by the serendipitous observation at MRI of two otherwise healthy young left-handed women, yet with no apparent OBs. Standardized tests revealed normal odor awareness, detection, discrimination, identification, and representation. Functional MRI of these women's brains revealed that odorant-induced activity in piriform cortex, the primary OB target, was similar in its extent to that of intact controls. Finally, review of a public brain-MRI database with 1,113 participants (606 women) also tested for olfactory performance, uncovered olfaction without anatomically defined OBs in ∼0.6% of women and ∼4.25% of left-handed women. Thus, humans can perform the basic facets of olfaction without canonical OBs, implying extreme plasticity in the functional neuroanatomy of this sensory system.
Identifiants
pubmed: 31706696
pii: S0896-6273(19)30854-2
doi: 10.1016/j.neuron.2019.10.006
pmc: PMC6953431
pii:
doi:
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-45.e5Subventions
Organisme : European Research Council
ID : 670798
Pays : International
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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