Correlation Between Allosteric and Orthosteric Sites.

Allosteric Regulation Allosteric Site Binding Sites Computer Simulation Drug Discovery Proteins / chemistry Structure-Activity Relationship
Community analysis Correlation Elastic network model Evolutionary analysis Molecular dynamics Mutual information Rigid-body simulation Statistical coupling analysis Two state Go̅ model

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2019
Historique:
entrez: 11 11 2019
pubmed: 11 11 2019
medline: 22 11 2019
Statut: ppublish

Résumé

Correlation between an allosteric site and its orthosteric site refers to the phenomenon that perturbations like ligand binding, mutation, or posttranslational modifications at the allosteric site leverage variation in the orthosteric site. Understanding this kind of correlation not only helps to disclose how information is transmitted in allosteric regulation but also provides clues for allosteric drug discovery. This chapter starts with an overview of correlation studies on allosteric and orthosteric sites and then introduces recent progress in evolutionary and simulation-based dynamic studies. Discussions and perspectives on future directions are also given.

Identifiants

DOI: 10.1007/978-981-13-8719-7_5 PMID: 31707701
pubmed: 31707701
doi: 10.1007/978-981-13-8719-7_5
doi:

Substances chimiques

Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

89-105

Auteurs

Weilin Zhang (W)

College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Center for Quantitative Biology, AAIS, Peking University, Beijing, China.

Juan Xie (J)

College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Center for Quantitative Biology, AAIS, Peking University, Beijing, China.

Luhua Lai (L)

College of Chemistry and Molecular Engineering, Peking University, Beijing, China. lhlai@pku.edu.cn.
Center for Quantitative Biology, AAIS, Peking University, Beijing, China. lhlai@pku.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Correlation Between Allosteric and Orthosteric Sites.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Site allostérique › Correlation Between Allosteric and Orthosteric Sites.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Correlation Between Allosteric and Orthosteric Sites.
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Correlation Between Allosteric and Orthosteric Sites.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Correlation Between Allosteric and Orthosteric Sites.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Correlation Between Allosteric and Orthosteric Sites.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Correlation Between Allosteric and Orthosteric Sites.