Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors.
Animals
Chromatin Assembly and Disassembly
/ immunology
Chromosomal Proteins, Non-Histone
/ genetics
DNA-Binding Proteins
/ genetics
Humans
Immunohistochemistry
/ methods
Mice, Inbred C57BL
Mice, Transgenic
Mutation
/ genetics
Nuclear Proteins
/ genetics
Rhabdoid Tumor
/ genetics
T-Lymphocytes
/ immunology
Transcription Factors
/ genetics
AT/RT
SMARCB1
SWI/SNF
T cell receptor
endogenous retrovirus
immunotherapy
pediatric cancer
rhabdoid tumor
single-cell RNA sequencing
tumor immunology
Journal
Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617
Informations de publication
Date de publication:
09 12 2019
09 12 2019
Historique:
received:
14
01
2019
revised:
06
08
2019
accepted:
22
10
2019
pubmed:
12
11
2019
medline:
28
5
2020
entrez:
12
11
2019
Statut:
ppublish
Résumé
Rhabdoid tumors (RTs) are genomically simple pediatric cancers driven by the biallelic inactivation of SMARCB1, leading to SWI/SNF chromatin remodeler complex deficiency. Comprehensive evaluation of the immune infiltrates of human and mice RTs, including immunohistochemistry, bulk RNA sequencing and DNA methylation profiling studies showed a high rate of tumors infiltrated by T and myeloid cells. Single-cell RNA (scRNA) and T cell receptor sequencing highlighted the heterogeneity of these cells and revealed therapeutically targetable exhausted effector and clonally expanded tissue resident memory CD8
Identifiants
pubmed: 31708437
pii: S1535-6108(19)30482-9
doi: 10.1016/j.ccell.2019.10.008
pii:
doi:
Substances chimiques
Chromosomal Proteins, Non-Histone
0
DNA-Binding Proteins
0
Nuclear Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-612.e8Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.