Elderly-onset Still's Disease Complicated by Macrophage Activation Syndrome: A Case Report and Review of the Literature.


Journal

Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241

Informations de publication

Date de publication:
01 Mar 2020
Historique:
pubmed: 12 11 2019
medline: 15 9 2020
entrez: 12 11 2019
Statut: ppublish

Résumé

Adult-onset Still's disease (AOSD) usually affects young adults. Some cases of elderly-onset Still's disease (EOSD) have been reported, but its clinical features are unclear. We herein report a 74-year-old woman who developed AOSD with macrophage activation syndrome (MAS). We also reviewed 24 previous EOSD cases in patients over 70 years old and compared the findings with overall AOSD. While the clinical features were similar between the two, including the presence of MAS, disseminated intravascular coagulation was more frequent in EOSD than in AOSD. Furthermore, despite a similar frequency of glucocorticoid use, immunosuppressants and biologics were less frequently administered in EOSD than in AOSD. This report highlights the fact that typical AOSD can develop in elderly patients with some characteristic features.

Identifiants

pubmed: 31708548
doi: 10.2169/internalmedicine.3727-19
pmc: PMC7086308
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

721-728

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Auteurs

Takuya Suda (T)

Department of Nephrology and Rheumatology, Ishikawa Prefectural Central Hospital, Japan.

Takeshi Zoshima (T)

Department of Rheumatology, Kanazawa University Graduate School of Medicine, Japan.

Akari Takeji (A)

Department of Nephrology and Rheumatology, Ishikawa Prefectural Central Hospital, Japan.

Yasunori Suzuki (Y)

Department of Nephrology and Rheumatology, Ishikawa Prefectural Central Hospital, Japan.

Ichiro Mizushima (I)

Department of Rheumatology, Kanazawa University Graduate School of Medicine, Japan.

Kazunori Yamada (K)

Department of Hematology and Immunology, Kanazawa Medical University, Japan.

Akikatsu Nakashima (A)

Department of Nephrology and Rheumatology, Ishikawa Prefectural Central Hospital, Japan.

Akihiro Yachie (A)

Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Japan.

Mitsuhiro Kawano (M)

Department of Rheumatology, Kanazawa University Graduate School of Medicine, Japan.

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