Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior.

invasiveness pituitary tumors recurrence resistance stem cells tumourigenesis

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2019
Historique:
received: 30 07 2019
accepted: 14 10 2019
entrez: 12 11 2019
pubmed: 12 11 2019
medline: 12 11 2019
Statut: epublish

Résumé

Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.

Identifiants

pubmed: 31708878
doi: 10.3389/fendo.2019.00745
pmc: PMC6823178
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

745

Informations de copyright

Copyright © 2019 Mantovani, Giardino, Treppiedi, Catalano, Mangili, Spada, Arosio and Peverelli.

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Auteurs

Giovanna Mantovani (G)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Elena Giardino (E)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Donatella Treppiedi (D)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Rosa Catalano (R)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
PhD Program in Endocrinological Sciences, Sapienza University of Rome, Rome, Italy.

Federica Mangili (F)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Anna Spada (A)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Maura Arosio (M)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Erika Peverelli (E)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Classifications MeSH