Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia.
Mongolia
Northeast Asia
adolescents
chemokines
cholecalciferol supplementation
cytokines
vitamin D deficiency
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
07
2019
accepted:
08
10
2019
entrez:
12
11
2019
pubmed:
12
11
2019
medline:
12
11
2019
Statut:
epublish
Résumé
Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient [blood 25(OH)D << 30 nmol/L] adolescents aged 12-15 from Mongolia. The study included 28 children receiving 800 IU daily cholecalciferol for 6 months spanning winter and spring, and 30 children receiving placebo during the same period. The levels of 25(OH)D were assessed at baseline, 3 and 6 months. Twenty-one cytokines were measured in serum at baseline and at 6 months. Changes in 25(OH)D and cytokines were assessed using paired parametric tests. The median blood 25(OH)D concentration at baseline was 13.7 nmol/L (IQR = 10.0-21.7). Supplementation tripled blood 25(OH)D levels (
Identifiants
pubmed: 31709259
doi: 10.3389/fnut.2019.00166
pmc: PMC6819500
doi:
Banques de données
ClinicalTrials.gov
['NCT01244204']
Types de publication
Journal Article
Langues
eng
Pagination
166Informations de copyright
Copyright © 2019 Yegorov, Bromage, Boldbaatar and Ganmaa.
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