Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway.
AKI, acute kidney injury
BM, bone marrow
BUN, blood urea nitrogen
Cr, creatinine
Gal-3, galectin-3
ICAM, intercellular adhesion molecule
ICU, intensive care unit
IL, interleukin
IR, ischemia-reperfusion
KDIGO, Kidney Disease Improving Global Outcome
KO, knock-out
MCP, modified citrus pectin
NT-proBNP, N-terminal-pro-brain natriuretic peptide
TGF, transforming growth factor
TNF, tumor necrosis factor
UUO, unilateral ureteral obstruction
WT, wild type
eGFR, estimated glomerular filtration rate
fibrosis
heart failure
inflammation
macrophages
renal failure
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
21
02
2019
revised:
29
05
2019
accepted:
04
06
2019
entrez:
12
11
2019
pubmed:
12
11
2019
medline:
12
11
2019
Statut:
epublish
Résumé
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.
Identifiants
pubmed: 31709320
doi: 10.1016/j.jacbts.2019.06.005
pii: S2452-302X(19)30188-3
pmc: PMC6834958
doi:
Types de publication
Journal Article
Langues
eng
Pagination
717-732Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 The Authors.
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