Morphological and Structural Properties of Amorphous Lactulose Studied by Scanning Electron Microscopy, Polarized Neutron Scattering, and Molecular Dynamics Simulations.

Calorimetry, Differential Scanning Crystallization Desiccation Drug Compounding / methods Drug Stability Freeze Drying Isomerism Lactulose / chemistry Microscopy, Electron, Scanning Molecular Dynamics Simulation Neutrons Particle Size Powders X-Ray Diffraction
amorphous sugar crystallites freeze-drying milling molecular dynamics simulation neutron diffraction quenching melt spray-drying structure

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
06 01 2020
Historique:
pubmed: 12 11 2019
medline: 18 11 2020
entrez: 12 11 2019
Statut: ppublish

Résumé

Morphological and structural properties of amorphous disaccharide lactulose (C

Identifiants

DOI: 10.1021/acs.molpharmaceut.9b00767 PMID: 31710493
pubmed: 31710493
doi: 10.1021/acs.molpharmaceut.9b00767
doi:

Substances chimiques

Powders 0
Lactulose 4618-18-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10-20

Auteurs

Frederic Ngono (F)

Universite de Lille, CNRS, INRA, ENSCL, UMR 8207 - UMET - Unité Matériaux et Transformations , F-59000 Lille , France.
Institut Laue Langevin , 71 Av. des Martyrs, CS 20156 , F-38042 Grenoble , France.
ORCID: 0000-0001-7880-5907

Gabriel J Cuello (GJ)

Institut Laue Langevin , 71 Av. des Martyrs, CS 20156 , F-38042 Grenoble , France.

Monica Jiménez-Ruiz (M)

Institut Laue Langevin , 71 Av. des Martyrs, CS 20156 , F-38042 Grenoble , France.
ORCID: 0000-0002-9856-807X

Jean-Francois Willart (JF)

Universite de Lille, CNRS, INRA, ENSCL, UMR 8207 - UMET - Unité Matériaux et Transformations , F-59000 Lille , France.
ORCID: 0000-0002-7911-3918

Mathieu Guerain (M)

Universite de Lille, CNRS, INRA, ENSCL, UMR 8207 - UMET - Unité Matériaux et Transformations , F-59000 Lille , France.

Andrew R Wildes (AR)

Institut Laue Langevin , 71 Av. des Martyrs, CS 20156 , F-38042 Grenoble , France.

Anne Stunault (A)

Institut Laue Langevin , 71 Av. des Martyrs, CS 20156 , F-38042 Grenoble , France.

Cherifa-Mounira Hamoudi-Ben Yelles (CM)

Inserm, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials , Universite de Lille , F-59000 Lille , France.

Frederic Affouard (F)

Universite de Lille, CNRS, INRA, ENSCL, UMR 8207 - UMET - Unité Matériaux et Transformations , F-59000 Lille , France.
ORCID: 0000-0001-8429-6416

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse thermique différentielle › Calorimétrie différentielle à balayage › Morphological and Structural Properties of...
questionsmedicales.fr › Phénomènes chimiques › Cristallisation › Morphological and Structural Properties of...
questionsmedicales.fr › Phénomènes chimiques › Dessiccation › Morphological and Structural Properties of...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Morphological and Structural Properties of...
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › Morphological and Structural Properties of...
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questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Morphological and Structural Properties of...
questionsmedicales.fr › Glucides › Sucres › Diholoside › Lactulose › Morphological and Structural Properties of...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Microscopie électronique à balayage › Morphological and Structural Properties of...
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