Antitubercular Triazines: Optimization and Intrabacterial Metabolism.
Animals
Antitubercular Agents
/ pharmacokinetics
Bacterial Proteins
/ antagonists & inhibitors
Drug Resistance, Bacterial
/ drug effects
Fatty Acid Synthases
/ antagonists & inhibitors
Female
Half-Life
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Mycobacterium tuberculosis
/ drug effects
Nitric Oxide
/ metabolism
Oxidoreductases
/ antagonists & inhibitors
Triazines
/ chemistry
Bayesian models
Mycobacterium tuberculosis
intrabacterial drug metabolism
nitrofuran
triazine
Journal
Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030
Informations de publication
Date de publication:
20 02 2020
20 02 2020
Historique:
received:
04
03
2019
revised:
02
09
2019
accepted:
22
10
2019
pubmed:
13
11
2019
medline:
14
5
2021
entrez:
13
11
2019
Statut:
ppublish
Résumé
The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F
Identifiants
pubmed: 31711854
pii: S2451-9456(19)30355-1
doi: 10.1016/j.chembiol.2019.10.010
pmc: PMC7035970
mid: NIHMS1543848
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Bacterial Proteins
0
Triazines
0
Nitric Oxide
31C4KY9ESH
F420H2 dehydrogenase
EC 1.-
Oxidoreductases
EC 1.-
InhA protein, Mycobacterium
EC 1.3.1.9
Fatty Acid Synthases
EC 2.3.1.85
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
172-185.e11Subventions
Organisme : NIH HHS
ID : S10 OD018206
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142731
Pays : United States
Organisme : NIAID NIH HHS
ID : R41 AI122434
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109713
Pays : United States
Organisme : NIH HHS
ID : S10 OD012346
Pays : United States
Organisme : NIH HHS
ID : S10 OD023524
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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