Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells.
Acute stroke
Blood-brain barrier
Connexin 43
Hemichannel
Pannexin 1
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
07
07
2019
revised:
18
10
2019
accepted:
07
11
2019
pubmed:
13
11
2019
medline:
8
1
2021
entrez:
13
11
2019
Statut:
ppublish
Résumé
Dysregulation of blood-brain barrier (BBB) transport exacerbates brain damage in acute ischemic stroke. Here, we aimed to investigate the mechanism of this BBB transport dysregulation by studying the localization and function of pannexin (Px) and connexin (Cx) hemichannels in blood-brain barrier endothelial cells of rat (TR-BBB13 cells) and human (hCMEC/D3 cells) under acute ischemic stroke-mimicking oxygen/glucose deprivation (OGD) and extracellular Ca
Identifiants
pubmed: 31712070
pii: S0197-0186(19)30370-5
doi: 10.1016/j.neuint.2019.104600
pii:
doi:
Substances chimiques
Connexin 43
0
Connexins
0
Gja1 protein, rat
0
Nerve Tissue Proteins
0
pannexin 1, rat
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104600Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.