Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
10 12 2019
10 12 2019
Historique:
received:
16
09
2018
accepted:
26
07
2019
pubmed:
13
11
2019
medline:
8
2
2020
entrez:
13
11
2019
Statut:
ppublish
Résumé
To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium. We harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis. In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethnoracial groups, some interethnic differences were found in the effects of risk factors on cognition. This study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethnoracial differences that warrant attention in the development of prevention strategies.
Identifiants
pubmed: 31712368
pii: WNL.0000000000008612
doi: 10.1212/WNL.0000000000008612
pmc: PMC6937495
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2257-e2271Subventions
Organisme : Medical Research Council
ID : G0300623
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100540
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J006971/1
Pays : United Kingdom
Investigateurs
Amy Brodtmann
(A)
Aleksandra Klimkowicz- Mrowiec
(A)
Martin Dichgans
(M)
Michael Hoffmann
(M)
Thomas Linden
(T)
Joanna Wardlaw
(J)
Charlotte Cordonnier
(C)
Vincent Mok
(V)
Informations de copyright
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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