Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 11 2019
11 11 2019
Historique:
received:
16
11
2018
accepted:
22
10
2019
entrez:
13
11
2019
pubmed:
13
11
2019
medline:
5
11
2020
Statut:
epublish
Résumé
The urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 ([TIMP-2]∙[IGFBP7]) have been introduced to improve risk prediction of severe acute kidney injury (AKI) within 12 hours of measurement. We performed a prospective cohort study to evaluate if the predictive value of [TIMP-2]∙[IGFBP7] for AKI might continue after 12 hours. We enrolled 442 critically ill adult patients from June to December 2016. Urine samples were collected at admission for [TIMP-2]∙[IGFBP7] measurement. Baseline patient characteristics were recorded including patients' demographics, prior health history, and the main reason for admission to build a logistic regression model to predict AKI. AKI occurrence differed between patients with [TIMP-2]∙[IGFBP7] ≤0.3 and >0.3 (ng/ml)
Identifiants
pubmed: 31712687
doi: 10.1038/s41598-019-52790-6
pii: 10.1038/s41598-019-52790-6
pmc: PMC6848119
doi:
Substances chimiques
Biomarkers
0
TIMP2 protein, human
0
Tissue Inhibitor of Metalloproteinase-2
127497-59-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16484Références
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