Initiation and Transmission of α-Synuclein Pathology in Parkinson's Disease.
Appendix
Exosomes
Gut
Neurodegeneration
Vagus nerve
Journal
Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461
Informations de publication
Date de publication:
11 Nov 2019
11 Nov 2019
Historique:
received:
05
08
2019
accepted:
18
10
2019
revised:
11
10
2019
entrez:
13
11
2019
pubmed:
13
11
2019
medline:
13
11
2019
Statut:
aheadofprint
Résumé
The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated forms of α-synuclein in the body. The location for the initiation of misfolded forms of α-synuclein is now a contentious issue, what was once thought to be a disease of the central nervous system (CNS) now appears to involve multiple organs in the body. In particular, the two regions in the body where the nervous system is exposed to the environment, the olfactory bulb and the enteric nervous system, are now thought to play an important role in the initial phase of the disease. Epidemiological studies point to the gastrointestinal tract, including the appendix, as a potential site for the misfolding and transmission of α-synuclein, with the vagus nerve providing a conduit between the gut and brain. A growing body of animal studies also support this pathway, implicating the transmission of pathological α-synuclein from outside the CNS in the development of PD.
Identifiants
pubmed: 31713092
doi: 10.1007/s11064-019-02896-0
pii: 10.1007/s11064-019-02896-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Health and Medical Research Council
ID : APP1164812
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