Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications.
angiogenesis
bioceramics
hydroxyapatite
in vitro testing
microRNA
osteogenesis
signaling pathways
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
10 Nov 2019
10 Nov 2019
Historique:
received:
30
09
2019
revised:
29
10
2019
accepted:
05
11
2019
entrez:
14
11
2019
pubmed:
14
11
2019
medline:
14
11
2019
Statut:
epublish
Résumé
Recently, a large spectrum of biomaterials emerged, with emphasis on various pure, blended, or doped calcium phosphates (CaPs). Although basic cytocompatibility testing protocols are referred by International Organization for Standardization (ISO) 10993 (parts 1-22), rigorous in vitro testing using cutting-edge technologies should be carried out in order to fully understand the behavior of various biomaterials (whether in bulk or low-dimensional object form) and to better gauge their outcome when implanted. In this review, current molecular techniques are assessed for the in-depth characterization of angiogenic potential, osteogenic capability, and the modulation of oxidative stress and inflammation properties of CaPs and their cation- and/or anion-substituted derivatives. Using such techniques, mechanisms of action of these compounds can be deciphered, highlighting the signaling pathway activation, cross-talk, and modulation by microRNA expression, which in turn can safely pave the road toward a better filtering of the truly functional, application-ready innovative therapeutic bioceramic-based solutions.
Identifiants
pubmed: 31717621
pii: ma12223704
doi: 10.3390/ma12223704
pmc: PMC6888321
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Romanian Ministry of Research and Innovation
ID : PN-III-P1-1.2-PCCDI-2017-0062/ctr.58; PN-III-P1-1.2-7PFE
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