Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting

Animals Female Larva / drug effects Life Cycle Stages / drug effects Male Ovum / drug effects Quinones / chemistry Schistosoma mansoni / drug effects Schistosomicides / pharmacology Structure-Activity Relationship
DFT calculations chemical synthesis of nature-inspired drug leads multistage activity redox-active compounds schistosomiasis thiazinoquinones

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
10 01 2020
Historique:
pubmed: 14 11 2019
medline: 15 12 2020
entrez: 14 11 2019
Statut: ppublish

Résumé

Schistosomiasis is the most significant neglected tropical parasitic disease caused by helminths in terms of morbidity and mortality caused by helminths. In this work, we present the antischistosomal activity against

Identifiants

DOI: 10.1021/acsinfecdis.9b00252 PMID: 31718145
pubmed: 31718145
doi: 10.1021/acsinfecdis.9b00252
doi:

Substances chimiques

Quinones 0
Schistosomicides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

124-137

Auteurs

Roberto Gimmelli (R)

Institute of Biochemistry and Cell Biology , National Research Council , Campus A. Buzzati-Traverso, Via E. Ramarini 32 , 00015 Monterotondo (Rome) , Italy.

Marco Persico (M)

The NeaNat Group, Department of Pharmacy , University of Naples "Federico II" , Via D. Montesano 49 , 80131 Napoli , Italy.
Centro Interuniversitario di Ricerca sulla Malaria/Italian Malaria Network , 06126 Perugia , Italy.

Concetta Imperatore (C)

The NeaNat Group, Department of Pharmacy , University of Naples "Federico II" , Via D. Montesano 49 , 80131 Napoli , Italy.
Centro Interuniversitario di Ricerca sulla Malaria/Italian Malaria Network , 06126 Perugia , Italy.

Fulvio Saccoccia (F)

Institute of Biochemistry and Cell Biology , National Research Council , Campus A. Buzzati-Traverso, Via E. Ramarini 32 , 00015 Monterotondo (Rome) , Italy.

Alessandra Guidi (A)

Institute of Biochemistry and Cell Biology , National Research Council , Campus A. Buzzati-Traverso, Via E. Ramarini 32 , 00015 Monterotondo (Rome) , Italy.

Marcello Casertano (M)

The NeaNat Group, Department of Pharmacy , University of Naples "Federico II" , Via D. Montesano 49 , 80131 Napoli , Italy.
Centro Interuniversitario di Ricerca sulla Malaria/Italian Malaria Network , 06126 Perugia , Italy.

Paolo Luciano (P)

The NeaNat Group, Department of Pharmacy , University of Naples "Federico II" , Via D. Montesano 49 , 80131 Napoli , Italy.
Centro Interuniversitario di Ricerca sulla Malaria/Italian Malaria Network , 06126 Perugia , Italy.

Agostina Pietrantoni (A)

Core Facilities , Italian National Institute of Health , Viale Regina Elena 299 , 00161 Rome , Italy.

Lucia Bertuccini (L)

Core Facilities , Italian National Institute of Health , Viale Regina Elena 299 , 00161 Rome , Italy.

Antonella Paladino (A)

Institute of Chemistry of Molecular Recognition , National Research Council , Via M. Bianco 9 , 20131 Milano , Italy.

Giuliana Papoff (G)

Institute of Biochemistry and Cell Biology , National Research Council , Campus A. Buzzati-Traverso, Via E. Ramarini 32 , 00015 Monterotondo (Rome) , Italy.

Marialuisa Menna (M)

The NeaNat Group, Department of Pharmacy , University of Naples "Federico II" , Via D. Montesano 49 , 80131 Napoli , Italy.
Centro Interuniversitario di Ricerca sulla Malaria/Italian Malaria Network , 06126 Perugia , Italy.
ORCID: 0000-0002-4515-3014

Caterina Fattorusso (C)

The NeaNat Group, Department of Pharmacy , University of Naples "Federico II" , Via D. Montesano 49 , 80131 Napoli , Italy.
Centro Interuniversitario di Ricerca sulla Malaria/Italian Malaria Network , 06126 Perugia , Italy.

Giovina Ruberti (G)

Institute of Biochemistry and Cell Biology , National Research Council , Campus A. Buzzati-Traverso, Via E. Ramarini 32 , 00015 Monterotondo (Rome) , Italy.
ORCID: 0000-0003-2367-9709

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Thiazinoquinones as New Promising Multistage...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Larve › Thiazinoquinones as New Promising Multistage...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Thiazinoquinones as New Promising Multistage...
questionsmedicales.fr › Structures de l'embryon › Ovule › Thiazinoquinones as New Promising Multistage...
questionsmedicales.fr › Composés chimiques organiques › Quinones › Thiazinoquinones as New Promising Multistage...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Trematoda › Schistosomatidae › Schistosoma › Schistosoma mansoni › Thiazinoquinones as New Promising Multistage...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques › Antihelminthiques antiplathelminthes › Schistosomicides › Thiazinoquinones as New Promising Multistage...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Thiazinoquinones as New Promising Multistage...