Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex.
Amino Acid Motifs
Animals
Axons
/ metabolism
Cell Membrane
/ metabolism
Cells, Cultured
Drosophila Proteins
/ chemistry
Drosophila melanogaster
/ metabolism
Fibroblasts
/ metabolism
Green Fluorescent Proteins
/ metabolism
Growth Cones
/ metabolism
Guanine Nucleotide Exchange Factors
/ chemistry
Membrane Proteins
/ chemistry
Mice
Microtubules
/ metabolism
NIH 3T3 Cells
Peptides
/ metabolism
Polymerization
Protein Domains
Pseudopodia
/ metabolism
D. melanogaster
Drosophila
axons
cell biology
cytoskeleton
developmental biology
microtubules
mouse
neurodegeneration
xenopus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
13 11 2019
13 11 2019
Historique:
received:
18
07
2019
accepted:
06
11
2019
pubmed:
14
11
2019
medline:
12
5
2020
entrez:
14
11
2019
Statut:
epublish
Résumé
Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in
Identifiants
pubmed: 31718774
doi: 10.7554/eLife.50319
pii: 50319
pmc: PMC6884004
doi:
pii:
Substances chimiques
Drosophila Proteins
0
Efa6 protein, Drosophila
0
Guanine Nucleotide Exchange Factors
0
Membrane Proteins
0
Peptides
0
Psd protein, mouse
0
Green Fluorescent Proteins
147336-22-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I002448/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P020151/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L000717/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M007553/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M007456/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J005983/1
Pays : United Kingdom
Organisme : Leverhulme Trust
ID : ECF-2017-247
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : VO 2071/1-1
Pays : International
Organisme : BBSRC
ID : BB/R018960/1
Pays : International
Informations de copyright
© 2019, Qu et al.
Déclaration de conflit d'intérêts
YQ, IH, ML, JP, AV, KD, AR, CF, VA, PO, NS, AP No competing interests declared
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