Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction.

Mini-Mental State Examination abnormal renal function cognitive dysfunction cystatin C ischemic stroke neural regeneration neuroprotective effect normal renal function

Journal

Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351

Informations de publication

Date de publication:
May 2020
Historique:
entrez: 14 11 2019
pubmed: 14 11 2019
medline: 14 11 2019
Statut: ppublish

Résumé

Stroke is the leading cause of death and long-term disability worldwide, and cognitive impairment and dementia are major complications of ischemic stroke. Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies. However, the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results. This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months. Data from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after stroke. According to the MMSE score, 308 patients (52.9%) had post-stroke cognitive dysfunction. After adjusting for potential confounding factors, the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30-0.98), compared with the lowest quartile. The correlation between serum CysC and cognitive dysfunction was modified by renal function status. We observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (P

Identifiants

DOI: 10.4103/1673-5374.268928 PMID: 31719258 PMC: PMC6990774
pubmed: 31719258
pii: NeuralRegenRes_2020_15_5_922_268928
doi: 10.4103/1673-5374.268928
pmc: PMC6990774
doi:

Banques de données

ClinicalTrials.gov
['NCT01840072']

Types de publication

Journal Article

Langues

eng

Pagination

922-928

Subventions

Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States

Déclaration de conflit d'intérêts

None

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Auteurs

Dao-Xia Guo (DX)

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China.

Zheng-Bao Zhu (ZB)

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China.

Chong-Ke Zhong (CK)

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Xiao-Qing Bu (XQ)

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Li-Hua Chen (LH)

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China.

Tan Xu (T)

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China.

Li-Bing Guo (LB)

Department of Neurology, Siping Central Hospital, Siping, Jilin Province, China.

Jin-Tao Zhang (JT)

Department of Neurology, the 88th Hospital of People's Liberation Army, Taian, Shandong Province, China.

Dong Li (D)

Department of Internal Medicine, Feicheng City People's Hospital, Feicheng, Shandong Province, China.

Jian-Hui Zhang (JH)

Department of Neurology, Tongliao Municipal Hospital, Inner Mongolia Autonomous Region, China.

Zhong Ju (Z)

Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Inner Mongolia Autonomous Region, China.

Chung-Shiuan Chen (CS)

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Jing Chen (J)

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.

Yong-Hong Zhang (YH)

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China.

Jiang He (J)

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.

Classifications MeSH