Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
12 11 2019
Historique:
received: 14 05 2019
accepted: 22 10 2019
entrez: 14 11 2019
pubmed: 14 11 2019
medline: 30 10 2020
Statut: epublish

Résumé

Cauda equina compression (CEC) is a major cause of neurogenic claudication and progresses to neuropathic pain (NP). A lipid mediator, lysophosphatidic acid (LPA), is known to induce NP via the LPA

Identifiants

pubmed: 31719574
doi: 10.1038/s41598-019-52999-5
pii: 10.1038/s41598-019-52999-5
pmc: PMC6851136
doi:

Substances chimiques

Lysophosphatidylcholines 0
Lysophospholipids 0
RNA, Messenger 0
Receptors, Lysophosphatidic Acid 0
lysophosphatidic acid PG6M3969SG

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16578

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Auteurs

Baasanjav Uranbileg (B)

Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.

Nobuko Ito (N)

Department of Anesthesiology and Pain Relief Center, The University of Tokyo, Tokyo, Japan. nobuko-tky@umin.ac.jp.

Makoto Kurano (M)

Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.

Daisuke Saigusa (D)

Department of Integrative Genomics, Tohoku Medical Megabank Organization, Miyagi, Japan.
Medical Biochemistry, Tohoku University School of Medicine, Sendai, Miyagi, Japan.

Ritsumi Saito (R)

Department of Integrative Genomics, Tohoku Medical Megabank Organization, Miyagi, Japan.
Medical Biochemistry, Tohoku University School of Medicine, Sendai, Miyagi, Japan.

Akira Uruno (A)

Department of Integrative Genomics, Tohoku Medical Megabank Organization, Miyagi, Japan.
Medical Biochemistry, Tohoku University School of Medicine, Sendai, Miyagi, Japan.

Kuniyuki Kano (K)

Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.

Hitoshi Ikeda (H)

Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.

Yoshitsugu Yamada (Y)

Department of Anesthesiology and Pain Relief Center, The University of Tokyo, Tokyo, Japan.

Masahiko Sumitani (M)

Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Miho Sekiguchi (M)

Department of Orthopaedic Surgery, Fukushima Medical University, School of Medicine, Fukushima, Japan.

Junken Aoki (J)

Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.

Yutaka Yatomi (Y)

Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.

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Classifications MeSH